Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Medical School of Nantong University, Nantong, Jiangsu 226001, China.
Pain Res Manag. 2024 Oct 30;2024:1109287. doi: 10.1155/2024/1109287. eCollection 2024.
The incidence of peripheral nerve injury (PNI) in China is continuously increasing. With an inability to function due to sensory and motor abnormalities, patients with PNI suffer from neuropathic pain and subsequent lesions. Presently, effective treatments for PNI are limited. To determine the role of neuroprotectin D1 (NPD1) in PNI, a sciatic nerve crush injury model was developed to investigate the impact of NPD1 on sensory and motor function recovery following nerve injury. The results demonstrated that NPD1 administered at different time points might reduce mechanical allodynia and thermal hyperalgesia caused by PNI, and its analgesic effect was not tolerated. Immunohistochemistry analyses revealed that administering NPD1 to PNI mice decreased the spinal microglia and astrocyte activation and decreased the inflammatory factor expression in the spinal dorsal horn. Furthermore, NPD1 can inhibit the invasion of IBA-1 macrophages in dorsal root ganglions generated by nerve injury. Meanwhile, it can help rehabilitate motor and neuromuscular functions following PNI. The results indicate that NPD1 may be involved in the sensory and motor function recovery following PNI.
在中国，周围神经损伤（PNI）的发病率持续上升。由于感觉和运动异常，PNI 患者会出现神经病理性疼痛和随后的损伤。目前，PNI 的有效治疗方法有限。为了确定神经保护素 D1（NPD1）在 PNI 中的作用，建立了坐骨神经挤压损伤模型，以研究 NPD1 对神经损伤后感觉和运动功能恢复的影响。结果表明，在不同时间点给予 NPD1 可能减轻 PNI 引起的机械性痛觉过敏和热痛觉过敏，且其镇痛作用可耐受。免疫组织化学分析显示，给予 PNI 小鼠 NPD1 可减少脊髓小胶质细胞和星形胶质细胞的激活，并减少脊髓背角的炎症因子表达。此外，NPD1 可抑制由神经损伤引起的背根神经节中 IBA-1 巨噬细胞的浸润。同时，它可以帮助 PNI 后恢复运动和神经肌肉功能。结果表明，NPD1 可能参与 PNI 后的感觉和运动功能恢复。
