费城染色体阴性慢性髓性白血病伴淋巴样干细胞原始细胞转化
Philadelphia-chromosome-negative chronic myelogenous leukemia with lymphoid stem cell blastic transformation.
作者信息
Kessler J F, Grogan T M, Greenberg B R
出版信息
Am J Hematol. 1985 Feb;18(2):201-6. doi: 10.1002/ajh.2830180211.
PMID:3855600
Abstract
A patient is described who had blastic transformation of Ph1 negative chronic myelogenous leukemia (Ph1 - CML). Characterization of the leukemic cells revealed a population with a lymphoid stem cell phenotype (cALL-, TdT+, Ia+, cIgM-). This particular phenotype may be responsible for the refractoriness to vincristine and prednisone and the rapid downhill course.
摘要
描述了一名患有Ph1阴性慢性粒细胞白血病（Ph1 - CML）急变期的患者。白血病细胞的特征显示为一群具有淋巴样干细胞表型的细胞（无普通型急性淋巴细胞白血病表型、末端脱氧核苷酸转移酶阳性、Ia阳性、膜表面免疫球蛋白M阴性）。这种特殊的表型可能是对长春新碱和泼尼松耐药以及病情迅速恶化的原因。
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