一种遗传性状与一个标记之间的关联：上位性与配子不平衡的区分。
Association between a genetic trait and a marker: discrimination between epistasis and gametic disequilibrium.
作者信息
Clerget-Darpoux F, Lathrop G M
出版信息
Hum Genet. 1985;69(2):188-9. doi: 10.1007/BF00293296.
PMID:3855838
Abstract
We reconsider the method of Ott and Falk (1982) for the analysis of genetic linkage and of epistasis in the presence of phenotypic association. Their approach is extended to allow for gametic disequilibrium between marker and trait loci. We show that epistasis and tight linkage with gametic disequilibrium may be indistinguishable as explanations of association even in a very large pedigree.
摘要
我们重新审视了奥特和福尔克（1982年）提出的在存在表型关联的情况下分析基因连锁和上位性的方法。他们的方法得到了扩展，以考虑标记位点和性状位点之间的配子不平衡。我们表明，即使在一个非常大的家系中，作为关联的解释，上位性和与配子不平衡的紧密连锁可能无法区分。
Zotero 插件