以眼球震颤和共济失调为表现的副肿瘤综合征病例
Paraneoplastic Syndrome Case Presented As Nystagmus and Ataxia.
作者信息
Darwesh Khaled M
机构信息
Internal Medicine, Providence St. Peter Hospital, Olympia, USA.
出版信息
Cureus. 2024 Feb 28;16(2):e55153. doi: 10.7759/cureus.55153. eCollection 2024 Feb.
Abstract
The incidence of paraneoplastic syndrome (PNS) is on the rise, attributed to the growing detection of antibody modalities in both the serum and cerebrospinal fluid (CSF). PNS can occur as different neurological symptoms. The revised guidelines streamline the diagnostic approach but identifying PNS still requires the detection of neurological manifestations concurrent with cancer, along with the presence of specific PNS autoantibodies.
摘要
副肿瘤综合征（PNS）的发病率正在上升，这归因于血清和脑脊液（CSF）中抗体模式检测的增加。PNS可表现为不同的神经症状。修订后的指南简化了诊断方法，但识别PNS仍需要检测与癌症同时出现的神经表现以及特定PNS自身抗体的存在。
相似文献
1
Paraneoplastic Syndrome Case Presented As Nystagmus and Ataxia.
Cureus. 2024 Feb 28;16(2):e55153. doi: 10.7759/cureus.55153. eCollection 2024 Feb.
2
Detection of paraneoplastic antibodies and their significance in paraneoplastic neurologic syndromes: a narrative review.
Ann Transl Med. 2023 Apr 15;11(7):283. doi: 10.21037/atm-21-2434. Epub 2022 Dec 19.
3
Anti-Homer-3 antibodies in cerebrospinal fluid and serum samples from a 58-year-old woman with subacute cerebellar degeneration and diffuse breast adenocarcinoma.
Neurol Res Pract. 2022 Jul 25;4(1):29. doi: 10.1186/s42466-022-00194-9.
4
Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association.
Brain. 2008 Oct;131(Pt 10):2553-63. doi: 10.1093/brain/awn183. Epub 2008 Aug 7.
5
SOX1 antibody-related paraneoplastic neurological syndromes: clinical correlates and assessment of laboratory diagnostic techniques.
J Neurol. 2023 Mar;270(3):1691-1701. doi: 10.1007/s00415-022-11523-y. Epub 2022 Dec 13.
6
Case report: Acute vestibular syndrome and cerebellitis in anti-Yo paraneoplastic syndrome.
Front Neurol. 2022 Aug 26;13:960584. doi: 10.3389/fneur.2022.960584. eCollection 2022.
7
Paraneoplastic Progressive Downbeat Nystagmus, Ataxia and Sensorineural Hearing Loss due to the ANTI-Kelch-11 Protein Antibody.
J Neuroophthalmol. 2021 Jun 1;41(2):261-265. doi: 10.1097/WNO.0000000000001194.
8
Anti-Ri-associated paraneoplastic ophthalmoplegia-ataxia syndrome in a woman with breast cancer: a case report and review of the literature.
J Med Case Rep. 2020 Jun 12;14(1):67. doi: 10.1186/s13256-020-02410-z.
9
Repetitive transcranial magnetic stimulation (rTMS) as a therapeutic option in paraneoplastic cerebellar ataxia - a case report.
J Med Life. 2022 Jun;15(6):860-866. doi: 10.25122/jml-2022-0156.
10
Paraneoplastic neurological syndromes.
Orphanet J Rare Dis. 2007 May 4;2:22. doi: 10.1186/1750-1172-2-22.
本文引用的文献
1
Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.
Neurol Neuroimmunol Neuroinflamm. 2021 May 18;8(4). doi: 10.1212/NXI.0000000000001014. Print 2021 Jul.
2
Paraneoplastic Neurologic Syndromes.
Neurol Clin. 2018 Aug;36(3):675-685. doi: 10.1016/j.ncl.2018.04.015. Epub 2018 Jun 18.
3
Paraneoplastic neurologic disorders in small cell lung carcinoma: A prospective study.
Neurology. 2015 Jul 21;85(3):235-9. doi: 10.1212/WNL.0000000000001721. Epub 2015 Jun 24.
4
Paraneoplastic neurological syndromes associated with ovarian tumors.
J Cancer Res Clin Oncol. 2015 Jan;141(1):99-108. doi: 10.1007/s00432-014-1745-9. Epub 2014 Jun 26.
5
Purkinje cell cytoplasmic autoantibody type 1 accompaniments: the cerebellum and beyond.
Arch Neurol. 2011 Oct;68(10):1282-9. doi: 10.1001/archneurol.2011.128. Epub 2011 Jun 13.
6
The origin of downbeat nystagmus: an asymmetry in the distribution of on-directions of vertical gaze-velocity Purkinje cells.
Ann N Y Acad Sci. 2005 Apr;1039:548-53. doi: 10.1196/annals.1325.065.
7
Recommended diagnostic criteria for paraneoplastic neurological syndromes.
J Neurol Neurosurg Psychiatry. 2004 Aug;75(8):1135-40. doi: 10.1136/jnnp.2003.034447.
8
Immunomodulatory treatment trial for paraneoplastic neurological disorders.
Neuro Oncol. 2004 Jan;6(1):55-62. doi: 10.1215/S1152851703000395.
9
Paraneoplastic syndromes of the spinal cord, nerve, and muscle.
Muscle Nerve. 2000 Dec;23(12):1800-18. doi: 10.1002/1097-4598(200012)23:12<1800::aid-mus3>3.0.co;2-x.
10
Small-cell lung cancer, paraneoplastic cerebellar degeneration and the Lambert-Eaton myasthenic syndrome.
Brain. 1997 Aug;120 ( Pt 8):1279-300. doi: 10.1093/brain/120.8.1279.
Zotero 插件