Zainuddin Siti Lailatul Akmar, Latib Norjehan, Taib Haslina, Ahmad Basaruddin, Sabarudin Muhammad Annurdin, Wan Mohamad Wan Majdiah
School of Dental Sciences, Universiti Sains Malaysia, Kelantan, MYS.
Unit of Periodontics, School of Dental Sciences, Universiti Sains Malaysia, Kelantan, MYS.
Cureus. 2024 Feb 28;16(2):e55167. doi: 10.7759/cureus.55167. eCollection 2024 Feb.
Locally delivered antibiotics are adjunctive therapies for the selective removal or inhibition of pathogenic microbes in combination with scaling and root planing (SRP) for the management of periodontitis.
The primary objective of this study was to evaluate the effectiveness of tetracycline fibers against minocycline gel when used as local drug delivery in conjunction with SRP for treating periodontitis.
This is a pilot randomized open single, blinded trial study comparing three treatment modalities: SRP with topical tetracycline fibers (SRP+T), SRP with topical minocycline HCL 2% gel (SRP+M), and SRP only as a control group. Probing pocket depth (PPD), clinical attachment loss (CAL), and bleeding on probing (BOP) percentages were recorded at baseline, one month, and at the end of three months. The data were subjected to analysis using IBM Corp. Released 2019. IBM SPSS Statistics for Windows, Version 26.0. Armonk, NY: IBM Corp. Repeated measures ANOVA was used to compare the clinical outcomes between the three treatment groups, accounting for the repeated measurements at baseline, one month, and three months. A p-value less than 0.05 at a 95% confidence interval was deemed statistically significant.
There were statistically significant changes within the groups in all the clinical parameters, including pocket depth, clinical attachment loss, and bleeding on probing score, at different time intervals, with the greatest mean pocket depth changes seen in the tetracycline group after one month (mean changes = 1.4 mm, P < 0.001) and over three months (mean changes = 1.79 mm, p < 0.001). For clinical attachment loss, after one month, the highest improvement in clinical level was seen in the minocycline group (mean changes = 0.7mm, p < 0.05), and the overall improvement was seen in the control group (mean changes = 1.1mm, p < 0.05). The minocycline group showed greater mean changes in bleeding on probing percentage, with the greatest changes after one month (mean changes = 19.34%, p < 0.001) and over three months (mean changes = 26.42%, p <0.001). However, there was no significant difference between the groups.
Locally delivered tetracycline and minocycline gel are effective as adjuncts to SRP and may improve the healing outcome in the management of periodontitis.
局部应用抗生素是一种辅助治疗方法，可与龈下刮治术和根面平整术（SRP）联合使用，用于选择性清除或抑制致病微生物，以治疗牙周炎。
本研究的主要目的是评估四环素纤维与米诺环素凝胶作为局部给药联合SRP治疗牙周炎时的有效性。
这是一项初步的随机开放单盲试验研究，比较三种治疗方式：SRP联合局部应用四环素纤维（SRP+T）、SRP联合局部应用2%盐酸米诺环素凝胶（SRP+M），以及仅进行SRP作为对照组。在基线、1个月和3个月末记录探诊深度（PPD）、临床附着丧失（CAL）和探诊出血（BOP）百分比。数据使用IBM公司2019年发布的Windows版IBM SPSS Statistics 26.0进行分析。采用重复测量方差分析比较三个治疗组之间的临床结果，同时考虑基线、1个月和3个月时的重复测量。在95%置信区间内，p值小于0.05被认为具有统计学意义。
在不同时间间隔内，所有临床参数（包括牙周袋深度、临床附着丧失和探诊出血评分）在各组内均有统计学显著变化，四环素组在1个月后（平均变化 = 1.4 mm，P < 0.001）和3个月后（平均变化 = 1.79 mm，p < 0.001）观察到最大的平均牙周袋深度变化。对于临床附着丧失，1个月后，米诺环素组观察到临床水平的最高改善（平均变化 = 0.7mm，p < 0.05），而总体改善在对照组中观察到（平均变化 = 1.1mm，p < 0.05）。米诺环素组在探诊出血百分比方面显示出更大的平均变化，1个月后变化最大（平均变化 = 19.34%，p < 0.001），3个月后（平均变化 = 26.42%，p <0.001）。然而，各组之间没有显著差异。
局部应用四环素和米诺环素凝胶作为SRP的辅助治疗有效，可能改善牙周炎治疗中的愈合效果。
