Montevecchi Marco, Valeriani Leoluca, Gatto Maria Rosaria, D'Alessandro Giovanni, Piana Gabriela
Division of Periodontology and Implantology, Department of Biomedical and Neuromotor Sciences, School of Dentistry, Alma Mater Studiorum - University of Bologna, Bologna, Italy.
Department of Biomedical and Neuromotor Sciences, School of Dentistry, Alma Mater Studiorum - University of Bologna, Bologna, Italy.
J Periodontal Implant Sci. 2021 Dec;51(6):409-421. doi: 10.5051/jpis.2100180009.
The aim of this study was to compare the prevalence and bacterial load of 6 main periodontal pathogens between pairs of periodontal patients with and without type 2 diabetes mellitus. and genotypes were also investigated.
Twenty patients affected by chronic periodontitis and type 2 diabetes were retrospectively selected and matched to 20 patients without diabetes on the basis of the degree and severity of periodontal disease. Microbiological data of subgingival biofilms were analysed and compared for the examined pathogens: , , , , , and .
The pairs were balanced in terms of demographic and clinical parameters, except for bleeding on probing and suppuration. In the microbiological test sites (4 for each patient), the mean probing pocket depth was 6.34±1.63 mm in patients with diabetes and 6.41±1.78 mm in patients without diabetes. No significant difference between pairs in the prevalence of or the distribution of its genotypes was recorded. Patients with diabetes had a significantly greater amount of total bacterial load, , , , and (<0.05). Moreover, patients with diabetes had a higher number of sites with a greater cell count than patients without diabetes. When compared to the total bacterial load, only maintained its relative load in patients with diabetes (=0.001).
This retrospective matched study supports the hypothesis that microbiological differences exist among periodontal patients with and without diabetes mellitus.
ClinicalTrials.gov Identifier: NCT03786133.
本研究旨在比较2型糖尿病牙周炎患者与非2型糖尿病牙周炎患者6种主要牙周病原体的患病率和细菌载量，并对其基因型进行研究。
回顾性选取20例慢性牙周炎合并2型糖尿病患者，并根据牙周疾病的程度和严重程度与20例非糖尿病患者进行匹配。分析并比较龈下生物膜中以下检测病原体的微生物学数据：[具体病原体名称]。
除探诊出血和化脓外，两组在人口统计学和临床参数方面保持平衡。在微生物检测部位（每位患者4个），糖尿病患者的平均探诊袋深度为6.34±1.63mm，非糖尿病患者为6.41±1.78mm。两组在[病原体名称]的患病率或其基因型分布上无显著差异。糖尿病患者的总细菌载量、[具体细菌名称]显著更高（<0.05）。此外，糖尿病患者中细胞计数较高的部位数量多于非糖尿病患者。与总细菌载量相比，只有[具体细菌名称]在糖尿病患者中保持其相对载量（=0.001）。
这项回顾性匹配研究支持了糖尿病牙周炎患者与非糖尿病牙周炎患者之间存在微生物学差异这一假设。
ClinicalTrials.gov标识符：NCT03786133。
