Malik Jahanzeb, Zaidi Syed Muhammad Jawad, Rana Abdul Sattar, Haider Ali, Tahir Saleha
Department of Cardiology, Rawalpindi Institute of Cardiology, Rawalpindi 46000, Pakistan.
Department of Medicine, Rawalpindi Medical University, Rawalpindi 46000, Pakistan.
Am Heart J Plus. 2021 Nov 19;12:100068. doi: 10.1016/j.ahjo.2021.100068. eCollection 2021 Dec.
Post-cardiac injury syndrome (PCIS) is an umbrella term used for the post-pericardiotomy syndrome, post-myocardial infarction (MI) related pericarditis (Dressler syndrome), and post-traumatic pericarditis (percutaneous coronary intervention (PCI) or cardiac implantable electronic device (CIED) placement). All these conditions give rise to PCIS due to an inciting cardiac injury to pericardial or pleural mesothelial cells, leading to subsequent inflammation syndromes ranging from uncomplicated pericarditis to massive pleural effusion. We did a literature search on MEDLINE/PubMed for relevant studies using the terms "post-acute cardiac injury syndrome", "post-cardiac injury syndrome", "post-cardiotomy syndrome", "post-pericardiotomy syndrome", "post-MI pericarditis" and to summarize the body of evidence, all relevant full texts were selected and incorporated in a narrative fashion. Pathophysiology of PCIS is suggested as autoimmune-mediated in predisposed patients who develop anti-actin and anti-myosin antibodies following a cascade of cardiac injury in various forms. Colchicine and NSAIDs including ibuprofen are demonstrated as efficacious in preventing recurrent attacks of PCIS while corticosteroids show no benefit on prognosis and recurrence of the disease.
心脏损伤后综合征（PCIS）是一个统称，用于涵盖心包切开术后综合征、心肌梗死（MI）相关心包炎（德雷斯勒综合征）以及创伤后心包炎（经皮冠状动脉介入治疗（PCI）或心脏植入式电子设备（CIED）置入术后）。所有这些情况均因对心包或胸膜间皮细胞的刺激性心脏损伤而引发PCIS，进而导致从单纯心包炎到大量胸腔积液等一系列炎症综合征。我们在MEDLINE/PubMed上使用“急性心脏损伤后综合征”“心脏损伤后综合征”“心包切开术后综合征”“心包切开术后综合征”“心肌梗死后心包炎”等术语进行了相关研究的文献检索，为总结证据，所有相关全文均被选取并以叙述方式纳入。PCIS的病理生理学被认为是在各种形式的心脏损伤后，易感患者中由自身免疫介导，随后产生抗肌动蛋白和抗肌球蛋白抗体。秋水仙碱和包括布洛芬在内的非甾体抗炎药已被证明可有效预防PCIS的复发，而皮质类固醇对该疾病的预后和复发并无益处。
