Millar Seán R, Harrington Janas M, Perry Ivan J, Phillips Catherine M
School of Public Health, University College Cork, Cork, Ireland.
School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin 4, Ireland.
Brain Behav Immun Health. 2024 Mar 18;37:100759. doi: 10.1016/j.bbih.2024.100759. eCollection 2024 May.
Mental disorders are a growing public health concern and evidence has linked chronic low-grade inflammation with depression and well-being. Research also suggests that certain modifiable lifestyle factors such as smoking, alcohol use, physical activity, diet quality and BMI are related to psychological health. These may modulate the relationship between low-grade inflammation and mental health conditions. In this study we examined inflammatory biomarker associations with two psychological health scores and investigated whether relationships are influenced by lifestyle factors and BMI.
This was a cross-sectional study of 1824 middle-to older-aged men and women randomly selected from a large primary care centre. Depressive symptoms and well-being were assessed using the 20-item Centre for Epidemiologic Studies Depression (CES-D) Scale and the World Health Organization-Five (WHO-5) Well-Being Index. Linear regression analyses were performed to examine depression and well-being score relationships with six inflammatory biomarkers, and a composite inflammatory biomarker score, adjusting for demographic characteristics, health conditions, lifestyle factors and BMI.
Depression and well-being score associations with complement component 3 (CES-D only) c-reactive protein, interleukin 6, leptin, white blood cell counts, neutrophils and the inflammatory biomarker score were observed. These relationships survived adjustment for demographic variables and health conditions but were attenuated in models which included lifestyle factors and BMI. In final models, only leptin (β = 0.566, = 0.018) and inflammatory score (β = 0.137, = 0.004) associations with the CES-D score remained.
These findings suggest that the relationship between systemic low-grade inflammation and depressive symptoms and well-being may be largely explained by lifestyle factors and adiposity, highlighting the potential importance of promoting a healthy lifestyle in the treatment of depressive disorders.
精神障碍日益引起公众对健康的关注，有证据表明慢性低度炎症与抑郁及幸福感有关。研究还表明，某些可改变的生活方式因素，如吸烟、饮酒、体育活动、饮食质量和体重指数（BMI）与心理健康有关。这些因素可能会调节低度炎症与心理健康状况之间的关系。在本研究中，我们检测了炎症生物标志物与两个心理健康评分之间的关联，并调查了这些关系是否受生活方式因素和BMI的影响。
这是一项横断面研究，从一个大型初级保健中心随机选取了1824名中老年男性和女性。使用20项流行病学研究中心抑郁量表（CES-D）和世界卫生组织五福（WHO-5）幸福感指数评估抑郁症状和幸福感。进行线性回归分析，以检验抑郁和幸福感评分与六种炎症生物标志物以及综合炎症生物标志物评分之间的关系，并对人口统计学特征、健康状况、生活方式因素和BMI进行校正。
观察到抑郁和幸福感评分与补体成分3（仅CES-D）、C反应蛋白、白细胞介素6、瘦素、白细胞计数、中性粒细胞以及炎症生物标志物评分之间存在关联。这些关系在对人口统计学变量和健康状况进行校正后仍然存在，但在纳入生活方式因素和BMI的模型中有所减弱。在最终模型中，仅瘦素（β = 0.566，P = 0.018）和炎症评分（β = 0.137，P = 0.004）与CES-D评分之间的关联仍然存在。
这些发现表明，全身性低度炎症与抑郁症状和幸福感之间的关系可能很大程度上由生活方式因素和肥胖来解释，这凸显了促进健康生活方式在抑郁症治疗中的潜在重要性。
