Chen Yaoheng, Zhang Hongzheng
Department of Otolaryngology Head and Neck Surgery，Affiliated Zhujiang Hospital of Southern Medical University；Department of Southern Medical University Hearing Research Center，Guangzhou，510220，China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2024 Apr;38(4):348-353. doi: 10.13201/j.issn.2096-7993.2024.04.017.
Various inner ear diseases such as sensorineural deafness and Meniere's disease bring about problems such as speech communication disorders and decreased work efficiency, which seriously affect the life quality of patients. Due to the special anatomical structure and blood-labyrinth barrier in the inner ear, the current drug administration methods are often unable to achieve satisfactory results. Nanocarriers are the forefront and hot spot of nanotechnology research. In recent years, a lot of research progress has been made in the field of targeted delivery of the inner ear, which is expected to be eventually applied to the treatment of clinical diseases of the inner ear. This review focuses on the advantages, main research achievements and limitations of various nanocarriers in the targeted delivery of the inner ear, hoping to provide new ideas for related research.
各种内耳疾病，如感音神经性耳聋和梅尼埃病，会引发言语交流障碍和工作效率下降等问题，严重影响患者的生活质量。由于内耳特殊的解剖结构和血迷路屏障，目前的给药方法往往无法取得令人满意的效果。纳米载体是纳米技术研究的前沿和热点。近年来，内耳靶向递送领域取得了许多研究进展，有望最终应用于内耳临床疾病的治疗。本文综述聚焦于各种纳米载体在内耳靶向递送中的优势、主要研究成果及局限性，希望为相关研究提供新思路。
