Liu Bo, Tu Yaqin, Wu Nan, Xiao Hongjun
Department of Otorhinolaryngology，Union Hospital of Tongji Medical College of Huazhong University of Science and Technology，Wuhan，430022，China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2025 Jan;39(1):91-96. doi: 10.13201/j.issn.2096-7993.2025.01.019.
Head and neck tumors are one of the major diseases that threaten human health. Targeted chemotherapy is an important treatment for head and neck tumors. However, many anti-cancer drugs are difficult to reach effective concentrations in tumors and can cause damage to normal tissues. Therefore, the efficient delivery of anti-tumor drugs, improvement of their therapeutic effects, and reduction of their adverse effects on the whole body and locally are urgent issues in targeted drug research. Liposomes have been widely studied due to their unique characteristics, including amphiphilicity, biocompatibility, biodegradability, and low toxicity. This article outlines the current applications and prospects of liposome drug delivery systems in different treatment modalities for head and neck tumors in recent years, aiming to provide more options for the treatment of head and neck tumors.
头颈部肿瘤是威胁人类健康的主要疾病之一。靶向化疗是头颈部肿瘤的重要治疗方法。然而，许多抗癌药物难以在肿瘤中达到有效浓度，并且会对正常组织造成损害。因此，高效递送抗肿瘤药物、提高其治疗效果以及减少其对全身和局部的不良反应是靶向药物研究中的紧迫问题。脂质体因其独特的特性，包括两亲性、生物相容性、生物可降解性和低毒性，而受到广泛研究。本文概述了近年来脂质体药物递送系统在头颈部肿瘤不同治疗方式中的应用现状和前景，旨在为头颈部肿瘤的治疗提供更多选择。
