[胸腺肽α1对小鼠淋巴细胞释放前列腺素的影响]
[Effect of thymosin alpha 1 on prostaglandin release by murine lymphocytes].
作者信息
Baldassarre A M, Stirparo G, Palamara A T, Padovani A, Mastino A
出版信息
Boll Soc Ital Biol Sper. 1985 Jan 30;61(1):23-6.
The effects on PGE2 release by lymphocytes obtained from adult thymectomized mice and from normal mice, after incubation with Thymosin alpha 1, were studied. Splenocytes from Tx mice release PGE2 at short time of incubation (15') using 4 micrograms/ml of Thymosin alpha 1 and at longer time of incubation (60'-180' using 4-8 micrograms/ml of Thymosin alpha 1. On the other hand thymocytes release the highest amounts of PGE2 after longer time of incubation (60'-180'). However lymphocytes obtained from normal mice do not release PGE2 amounts comparable with that released by the control samples. This effect shows an interesting interaction between thymic hormones and PGs.
研究了从成年去胸腺小鼠和正常小鼠获取的淋巴细胞在与胸腺素α1孵育后对前列腺素E2（PGE2）释放的影响。去胸腺小鼠的脾细胞在短时间孵育（15分钟）时，使用4微克/毫升的胸腺素α1释放PGE2，在较长时间孵育（60 - 180分钟）时，使用4 - 8微克/毫升的胸腺素α1释放PGE2。另一方面，胸腺细胞在较长时间孵育（60 - 180分钟）后释放的PGE2量最高。然而，从正常小鼠获取的淋巴细胞释放的PGE2量与对照样品释放的量不可比。这种效应显示了胸腺激素和前列腺素之间有趣的相互作用。
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