胸腺素的作用是由前列腺素释放介导的吗？

Is thymosin action mediated by prostaglandin release?

作者信息

Rinaldi Garaci C, Favalli C, Del Gobbo V, Garaci E, Jaffe B M

出版信息

Science. 1983 Jun 10;220(4602):1163-4. doi: 10.1126/science.6574601.

Abstract

Treatment of spleen cells derived from adult thymectomized mice with thymosin fraction 5 resulted in a rapid and dose-dependent stimulation of the release of immunoreactive prostaglandin E2. The release of prostaglandin E2 was associated with induction of theta antigen and was totally inhibited by indomethacin. In contrast, prostaglandin E2 release from spleen cells from intact donors was inhibited by treatment with fraction 5. The data support the concept that prostaglandin E2 mediates the effects of thymosin fraction 5 on lymphocytes.

摘要

用胸腺素5组分处理成年去胸腺小鼠的脾细胞，会导致免疫反应性前列腺素E2的释放迅速且呈剂量依赖性地受到刺激。前列腺素E2的释放与θ抗原的诱导相关，并且完全被吲哚美辛抑制。相比之下，完整供体的脾细胞经5组分处理后，前列腺素E2的释放受到抑制。这些数据支持前列腺素E2介导胸腺素5组分对淋巴细胞作用的概念。