[Release of prostaglandins by spleen cells in the mouse after incubation with thymosin].

The effects of i.p. administration in mice of a rabbit antiserum specific for thymic epithelial cells on T-dependent cellular immune response has been studied. As measure of T-dependent cellular immune response were taken: 1) a delayed type hypersensitivity test based on the swelling of footpad following SRBC injection in immunized mice; 2) a graft-versus-host assay valuated by splenomegaly induced in newborn mice after donors mice spleen cells i.p. injection. Both assays showed a significant reduction of cellular T-dependent immune response. The cinetic of this effect is in accord with ultrastructural changes in mice thymus, following the same treatment, previously observed.