Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
PLoS One. 2024 Oct 16;19(10):e0310184. doi: 10.1371/journal.pone.0310184. eCollection 2024.
The association between dietary carbohydrate intake and hyperlipidemia remained incompletely understood. This study aimed to explore the association between dietary carbohydrate intake and the risk of hyperlipidemia among reproductive-aged women in the US.
The study utilized data from the National Health and Nutrition Examination Survey (NHANES) conducted from 2005 to 2020. Dietary intake information was assessed via interviews using 24-hour dietary recall interviews, and hyperlipidemia diagnosis adhered to the National Cholesterol Education Program guidelines. Univariate and multivariate logistic regression analyses, along with restricted cubic splines (RCS) and stratified analyses, were conducted to investigate the association between dietary carbohydrate intake and the risk of hyperlipidemia.
A total of 6,791 women of reproductive age, with a mean age of 34.87 (±8.57) years, were included in the final analysis. In the multivariate logistic regression model adjusting for covariates, a higher percentage of energy from carbohydrate was positively correlated with the risk of hyperlipidemia (adjusted odds ratio (AOR): 1.014, 95% CI: 1.004-1.024). Analyzing the percentage of energy from carbohydrate as a categorical variable, compared to the lowest quartile, the third quartile (AOR: 1.263, 95% CI: 1.031-1.546) and the highest quartile (AOR: 1.411, 95% CI: 1.083-1.839) were associated with increased hyperlipidemia risk. Additionally, a linear relationship (P for nonlinearity = 0.088) existed between the percentage of energy from carbohydrate and the risk of hyperlipidemia, with an inflection point identified at 49.64.
This study found that elevated dietary carbohydrate intake was associated with an increased the risk of hyperlipidemia in reproductive-aged women. These findings implied that reproductive-aged women should pay closer attention to reducing their carbohydrate intake.
膳食碳水化合物摄入量与高脂血症之间的关联仍不完全清楚。本研究旨在探讨美国育龄妇女膳食碳水化合物摄入量与高脂血症风险之间的关系。
本研究使用了 2005 年至 2020 年进行的国家健康和营养检查调查（NHANES）的数据。通过 24 小时膳食回忆访谈进行膳食摄入信息评估，高脂血症诊断遵循国家胆固醇教育计划指南。采用单变量和多变量逻辑回归分析、限制立方样条（RCS）和分层分析，研究膳食碳水化合物摄入量与高脂血症风险之间的关系。
共纳入 6791 名育龄妇女，平均年龄为 34.87（±8.57）岁，最终纳入分析。在调整协变量的多变量逻辑回归模型中，碳水化合物能量百分比越高与高脂血症风险呈正相关（调整后的优势比（AOR）：1.014，95%置信区间（CI）：1.004-1.024）。分析碳水化合物能量百分比作为分类变量，与最低四分位相比，第三四分位（AOR：1.263，95%CI：1.031-1.546）和最高四分位（AOR：1.411，95%CI：1.083-1.839）与高脂血症风险增加相关。此外，碳水化合物能量百分比与高脂血症风险之间存在线性关系（非线性 P 值=0.088），拐点为 49.64。
本研究发现，升高的膳食碳水化合物摄入量与育龄妇女高脂血症风险增加有关。这些发现表明，育龄妇女应更加注意减少碳水化合物的摄入。
