Shah V K, Ugalde R A, Imperial J, Brill W J
J Biol Chem. 1985 Apr 10;260(7):3891-4.
Tetrathiomolybdate inhibits iron-molybdenum cofactor (FeMo cofactor) binding to component I of nitrogenase. Molybdenum-iron cluster (a subcomponent of FeMo cofactor) and tetrathiomolybdate inhibited FeMo cofactor activation of inactive nitrogenase component I in extracts of Azotobacter vinelandii and Klebsiella pneumoniae mutant strains defective in the biosynthesis of FeMo cofactor. Addition of tetrathiotungstate, the tungsten analog of tetrathiomolybdate, to the mutant extracts had no significant inhibitory effect on subsequent activation by FeMo cofactor.
四硫代钼酸盐抑制铁钼辅因子（FeMo辅因子）与固氮酶组分I的结合。钼铁簇（FeMo辅因子的一个亚组分）和四硫代钼酸盐抑制了在棕色固氮菌和肺炎克雷伯氏菌突变株提取物中，FeMo辅因子对无活性固氮酶组分I的激活作用，这些突变株在FeMo辅因子的生物合成方面存在缺陷。向突变株提取物中添加四硫代钨酸盐（四硫代钼酸盐的钨类似物），对随后FeMo辅因子的激活没有显著抑制作用。
