Eslami Hadi, Tohidi Reyhaneh, Ranjbar Faezeh Esmaeili, Moetamed Soheil, Vatanparast Mahboubeh
Department of Otorhinolaryngology Head and Neck Surgery, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran.
Department of Ophthalmology and otorhinolaryngology, Clinical Research Development Unit (CRDU), Moradi Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Indian J Otolaryngol Head Neck Surg. 2024 Apr;76(2):1819-1824. doi: 10.1007/s12070-023-04418-5. Epub 2023 Dec 12.
Reinke's edema (RE) is a benign pathological non-inflammatory disorder of the vocal folds with a wide range of clinical manifestations. We aim to investigate the relationship between Reinke's edema and some common inhalant abuse. In this case-control study, subjective consisted of 23 patients with RE (the cases), and 50 patients with sinusitis (control) who underwent surgery in the Department of Otolaryngology, between 2015 and 2020. Demographic characteristics, history of some related disease, methods, and the duration of cigarette, and opium consumption were collected through the patients' files. The chi-square test was run to analyze the differences in the categorical and, and the Independent Sample T-test was used to compare two sample means from unrelated groups. A significant level (p-value) was considered less than 0.05. The mean age was 54 ± 12 years, and 42 ± 11 years, respectively for Reinke's edema and sinusitis. More women had been recorded in the RE group, compared to men. Allergy, unprincipled use of voice and talkativeness, history of laryngeal surgery, and type of disease were correlated to RE (p < 0.05). Also, cigarette smoking was significantly correlated with Reinke's edema. The average number of cigarettes per day, the duration of smoking, and opium consumption were more frequent in RE (P < 0.05). 90% of the RE and 4% of sinusitis patients were opium consumers. There was a statistically significant difference in the methods of substance use in the two groups of cases and control (p < 0.0001). Among the different methods, the poker and stone method was the most common (69.6%), and the opium smoking pipe was the second most common method. This study also confirmed the hazardous effects of smoking and inhaling opiates in the formation of lesions of the pharynx and larynx. In particular, longer use of these substances will be associated with more serious side effects. Therefore, it seems that people who are addicted to opiates should undergo periodic visits and counseling to reduce and stop their use.
任克氏水肿（RE）是一种声带的良性病理性非炎症性疾病，临床表现多样。我们旨在研究任克氏水肿与一些常见吸入性物质滥用之间的关系。在这项病例对照研究中，主观研究对象包括2015年至2020年间在耳鼻喉科接受手术的23例任克氏水肿患者（病例组）和50例鼻窦炎患者（对照组）。通过患者档案收集人口统计学特征、一些相关疾病史、方法以及吸烟和吸食鸦片的持续时间。采用卡方检验分析分类差异，独立样本t检验用于比较不相关组的两个样本均值。显著性水平（p值）设定为小于0.05。任克氏水肿组和鼻窦炎组的平均年龄分别为54±12岁和42±11岁。与男性相比，任克氏水肿组记录的女性更多。过敏、无节制使用嗓音和健谈、喉部手术史以及疾病类型与任克氏水肿相关（p<0.05）。此外，吸烟与任克氏水肿显著相关。任克氏水肿组每天吸烟的平均数量、吸烟持续时间和吸食鸦片的频率更高（P<0.05）。90%的任克氏水肿患者和4%的鼻窦炎患者吸食鸦片。两组病例和对照组在物质使用方法上存在统计学显著差异（p<0.0001）。在不同方法中，扑克和石头法最常见（69.6%），鸦片烟枪法是第二常见的方法。本研究还证实了吸烟和吸入鸦片制剂对咽喉部病变形成的有害影响。特别是，长期使用这些物质会带来更严重的副作用。因此，似乎对鸦片制剂成瘾的人应该定期就诊并接受咨询，以减少和停止使用。
