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沉香中的倍半萜类化合物和六降葫芦素通过抑制STAT1/AKT/MAPK/NLRP3途径发挥抗炎作用。

Sesquiterpenoids and hexanorcucurbitacin from agarwood with anti-inflammatory effects by inhibiting the STAT1/AKT/MAPK/NLRP3 pathway.

作者信息

Ma Chi Thanh, Huang Tianqi, Yu Jae Sik, Ly Tu Loan, Vu Huynh Kim Long, Kwon Sung Won, Park Jeong Hill, Yang Hyun Ok

机构信息

Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City 41-43 Dinh Tien Hoang St, Dist 1 Ho Chi Minh City 700000 Vietnam

Department of Integrative Biological Sciences and Industry & Convergence Research Center for Natural Products, Sejong University 209, Neungdong-ro, Gwangjin-gu Seoul 05006 Republic of Korea

出版信息

RSC Adv. 2024 Apr 2;14(13):9391-9405. doi: 10.1039/d3ra08686k. eCollection 2024 Mar 14.

DOI:10.1039/d3ra08686k
PMID:38566784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10985734/
Abstract

Seven unknown compounds 1-7, including four sesquiterpenoids, one azulene-type, one indene-type, and one rare hexanorcucurbitacin, together with eleven knowns ones (8-16), were isolated from the agarwood chips of . The structures of the isolated compounds were elucidated by extensive spectroscopic methods such as mass spectrometry, UV, IR, NMR spectroscopy. The precise stereo-chemical configurations of new compounds were determined by calculated ECD spectra data, as well as a single-crystal X-ray diffraction analysis. The isolated compounds 1-7 were evaluated by estimating the levels of nitric oxide (NO), TNF-α, and the expression of enzyme iNOS, and COX-2. Among them, a rare hexanortriterpenoid (7) derived from a cucurbitane-type triterpenoid showed the significantly attenuated neuro-inflammatory effects the STAT1/AKT/MAPK/NLRP3 signaling pathway on the mechanistic studies.

摘要

从[沉香木片]中分离出7种未知化合物1 - 7，包括4种倍半萜、1种薁类、1种茚类和1种罕见的六降葫芦素，以及11种已知化合物（8 - 16）。通过质谱、紫外、红外、核磁共振光谱等多种光谱方法对分离得到的化合物结构进行了鉴定。通过计算ECD光谱数据以及单晶X射线衍射分析确定了新化合物的精确立体化学构型。通过评估一氧化氮（NO）、肿瘤坏死因子-α（TNF-α）水平以及酶诱导型一氧化氮合酶（iNOS）和环氧化酶-2（COX-2）的表达，对分离得到的化合物1 - 7进行了评估。其中，一种源自葫芦烷型三萜的罕见六降三萜（7）在机制研究中对STAT1/AKT/MAPK/NLRP3信号通路显示出显著的神经炎症减轻作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/5a56c020bed0/d3ra08686k-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/619e76e1b09f/d3ra08686k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/5368f221eb65/d3ra08686k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/fda00930739d/d3ra08686k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/9433825a2139/d3ra08686k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/34e10eaa5567/d3ra08686k-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/0661ac06715f/d3ra08686k-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/3c20092c107f/d3ra08686k-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/0faef06b8578/d3ra08686k-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/95265dbe7709/d3ra08686k-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/5a56c020bed0/d3ra08686k-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/619e76e1b09f/d3ra08686k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/5368f221eb65/d3ra08686k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/fda00930739d/d3ra08686k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/9433825a2139/d3ra08686k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/34e10eaa5567/d3ra08686k-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/0661ac06715f/d3ra08686k-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/3c20092c107f/d3ra08686k-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/0faef06b8578/d3ra08686k-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/95265dbe7709/d3ra08686k-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418b/10985734/5a56c020bed0/d3ra08686k-f10.jpg

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