Li Xiaojing, Liu Qiaohong, Pan Yuqing, Chen Si, Zhao Yu, Hu Yiyang
Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Institute of Liver Diseases, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Institute of Clinical Pharmacology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Pharmacol. 2023 Feb 2;14:1097835. doi: 10.3389/fphar.2023.1097835. eCollection 2023.
The incidence of obesity and associated metabolic diseases is increasing globally, adversely affecting human health. Dietary fats, especially triglycerides, are an important source of energy for the body, and the intestine absorbs lipids through a series of orderly and complex steps. A long-term high-fat diet leads to intestinal dysfunction, inducing obesity and metabolic disorders. Therefore, regulating dietary triglycerides absorption is a promising therapeutic strategy. In this review, we will discuss diverse aspects of the dietary triglycerides hydrolysis, fatty acid uptake, triglycerides resynthesis, chylomicron assembly, trafficking, and secretion processes in intestinal epithelial cells, as well as potential targets in this process that may influence dietary fat-induced obesity and metabolic diseases. We also mention the possible shortcomings and deficiencies in modulating dietary lipid absorption targets to provide a better understanding of their administrability as drugs in obesity and related metabolic disorders.
全球范围内，肥胖及相关代谢性疾病的发病率正在上升，对人类健康产生不利影响。膳食脂肪，尤其是甘油三酯，是身体重要的能量来源，肠道通过一系列有序且复杂的步骤吸收脂质。长期高脂饮食会导致肠道功能紊乱，引发肥胖和代谢紊乱。因此，调节膳食甘油三酯的吸收是一种很有前景的治疗策略。在这篇综述中，我们将讨论肠道上皮细胞中膳食甘油三酯的水解、脂肪酸摄取、甘油三酯再合成、乳糜微粒组装、运输和分泌过程的各个方面，以及该过程中可能影响膳食脂肪诱导的肥胖和代谢性疾病的潜在靶点。我们还提到了调节膳食脂质吸收靶点可能存在的缺点和不足，以便更好地理解它们作为肥胖及相关代谢紊乱治疗药物的适用性。
