Research Core Facility of West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Nephrology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Front Endocrinol (Lausanne). 2024 Mar 19;15:1369968. doi: 10.3389/fendo.2024.1369968. eCollection 2024.
This study aims to investigate the association between lactate dehydrogenase (LDH) and the risk of diabetic kidney disease (DKD) in patients with type 2 diabetes (T2D).
The study enrolled patients with diagnosis of T2D between 2009 and 2018 from the National Nutrition and Health Examination Survey (NHANES) database. Demographic information, laboratory test, and diagnostic data were collected. Restricted cubic spline (RCS) plots were used to assess the dose-effect relationship between LDH levels and the risk of DKD in patients with T2D. Based on LDH levels, individuals were divided into higher and lower groups using dichotomy, and multivariate logistic regression analysis was conducted to explore the relationship between different LDH levels and the risk of DKD in T2D patients. Stratified analysis was performed to assess the consistency of the result.
A total of 4888 patients were included in the study, with 2976 (60.9%) patients without DKD and 1912 (39.1%) patients with DKD. RCS plots showed that the risk of DKD increased with increasing LDH levels. Multifactorial logistic regression analysis revealed that T2D patients with higher LDH levels had a 45% increased risk of DKD compared to those with lower LDH levels (OR=1.45; 95% CI: 1.11-1.89). Furthermore, each standard deviation increase in LDH level was associated with a 24% increase in DKD incidence among T2D patients (OR=1.24; 95% CI: 1.07-1.44). Stratified analysis consistently supported these findings.
LDH can serve as a valuable biomarker for screening DKD in patients with T2D.
本研究旨在探讨乳酸脱氢酶（LDH）与 2 型糖尿病（T2D）患者发生糖尿病肾脏疾病（DKD）的风险之间的关系。
本研究纳入了 2009 年至 2018 年期间来自全国营养与健康调查（NHANES）数据库的 T2D 诊断患者。收集了人口统计学信息、实验室检查和诊断数据。采用限制性立方样条（RCS）图评估 LDH 水平与 T2D 患者 DKD 风险之间的剂量-效应关系。根据 LDH 水平，将个体分为高低两组，并采用多因素 logistic 回归分析探讨不同 LDH 水平与 T2D 患者 DKD 风险之间的关系。进行分层分析以评估结果的一致性。
本研究共纳入 4888 例患者，其中 2976 例（60.9%）患者无 DKD，1912 例（39.1%）患者患有 DKD。RCS 图显示，随着 LDH 水平的升高，DKD 的发病风险增加。多因素 logistic 回归分析显示，与 LDH 水平较低的患者相比，LDH 水平较高的 T2D 患者发生 DKD 的风险增加了 45%（OR=1.45；95%CI：1.11-1.89）。此外，LDH 水平每增加一个标准差，T2D 患者发生 DKD 的风险增加 24%（OR=1.24；95%CI：1.07-1.44）。分层分析一致支持这些发现。
LDH 可作为 T2D 患者筛查 DKD 的有价值的生物标志物。
