Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.
Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.
Food Funct. 2024 Apr 22;15(8):4503-4514. doi: 10.1039/d4fo00483c.
Caloric restriction is an effective means of extending a healthy lifespan. Fasting mimicking diet (FMD) is a growing pattern of caloric restriction. We found that FMD significantly prolonged the lifespan of prematurely aging mice. In naturally aging mice, FMD improved cognitive and intestinal health. Through a series of behavioral experiments, we found that FMD relieved anxiety and enhanced cognition in aged mice. In the intestine, the FMD cycles enhanced the barrier function, reduced senescence markers, and maintained T cell naïve-memory balance in the lamina propria mucosa. To further explore the causes of immune alterations, we examined changes in the stool microbiota using 16S rRNA sequencing. We found that FMD remodeled gut bacterial composition and significantly expanded the abundance of . Our research revealed that FMD has in-depth investigative value as an anti-aging intervention for extending longevity and improving cognition, intestinal function, and gut microbiota composition.
热量限制是延长健康寿命的有效手段。限时进食模拟（FMD）是一种新兴的热量限制模式。我们发现 FMD 可显著延长早衰小鼠的寿命。在自然衰老的小鼠中，FMD 改善了认知和肠道健康。通过一系列行为实验，我们发现 FMD 可缓解老年小鼠的焦虑并增强其认知能力。在肠道中，FMD 循环增强了屏障功能，减少了衰老标志物，并维持了固有层黏膜中 T 细胞初始-记忆平衡。为了进一步探究免疫改变的原因，我们使用 16S rRNA 测序检查了粪便微生物组的变化。我们发现 FMD 重塑了肠道细菌组成，显著增加了 的丰度。我们的研究表明，FMD 具有深入的研究价值，可作为一种抗衰老干预措施，延长寿命，改善认知、肠道功能和肠道微生物组成。
