活体显微镜证据表明亚甲蓝在脓毒性血管扩张性休克中应作为血管加压剂的节约剂。
Intravital Microscopy Evidence That Methylene Blue Should Be a Vasopressor-Sparing Agent in Sepsis Vasoplegia.
机构信息
Department of Surgery and Anatomy, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Department of Biological Sciences, Faculdade de Odontologia de Bauru, Universidade de São Paulo, Bauru, São Paulo, Brazil.
出版信息
Braz J Cardiovasc Surg. 2024 Apr 3;39(3):e20230066. doi: 10.21470/1678-9741-2023-0066.
Microvasculature failure is expected in sepsis and at higher amine concentrations. Therefore, special attention focused individually on microcirculation is needed. Here, we present that methylene blue can prevent leukocytes from adhering to the endothelium in a rat model of lipopolysaccharide-induced endotoxemia. As hypothesis evidence, an intravital microscopy image is presented.
微脉管系统衰竭预计会在脓毒症和更高的胺浓度下发生。因此，需要特别关注个体的微循环。在这里，我们提出亚甲蓝可以防止白细胞在脂多糖诱导的内毒素血症的大鼠模型中黏附在内皮上。作为假设证据，呈现了一个活体显微镜图像。
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