Chongqing Key Laboratory of Micro-Nano Systems and Intelligent Transduction, Collaborative Innovation Center on Micro-Nano Transduction and Intelligent Eco-Internet of Things, Chongqing Key Laboratory of Colleges and Universities on Micro-Nano Systems Technology and Smart Transducing, National Research Base of Intelligent Manufacturing Service, School of Mechanical Engincering, Chongqing Technology and Business University, Nan'an District, Chongqing, 400067, China; X Multidisciplinary Research Institute, Faculty of Instrumentation Science and Technology, State Key Laboratory for Manufacturing Systems Engineering, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, Xi'an Jiaotong University, Xi'an, 710049, China; Department of Microsystems- IMS, Faculty of Technology, Natural Sciences and Maritime Sciences, University of South-Eastern Norway-USN, P.O. Box 235, Kongsberg, 3603, Norway.
Chongqing Key Laboratory of Micro-Nano Systems and Intelligent Transduction, Collaborative Innovation Center on Micro-Nano Transduction and Intelligent Eco-Internet of Things, Chongqing Key Laboratory of Colleges and Universities on Micro-Nano Systems Technology and Smart Transducing, National Research Base of Intelligent Manufacturing Service, School of Mechanical Engincering, Chongqing Technology and Business University, Nan'an District, Chongqing, 400067, China; X Multidisciplinary Research Institute, Faculty of Instrumentation Science and Technology, State Key Laboratory for Manufacturing Systems Engineering, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, Xi'an Jiaotong University, Xi'an, 710049, China.
Biosens Bioelectron. 2024 Jul 1;255:116090. doi: 10.1016/j.bios.2024.116090. Epub 2024 Feb 5.
Cardiovascular diseases (CVDs), especially chronic heart failure, threaten many patients' lives worldwide. Because of its slow course and complex causes, its clinical screening, diagnosis, and prognosis are essential challenges. Clinical biomarkers and biosensor technologies can rapidly screen and diagnose. Multiple types of biomarkers are employed for screening purposes, precise diagnosis, and treatment follow-up. This article provides an up-to-date overview of the biomarkers associated with the six main heart failure etiology pathways. Plasma natriuretic peptides (BNP and NT-proBNP) and cardiac troponins (cTnT, cTnl) are still analyzed as gold-standard markers for heart failure. Other complementary biomarkers include growth differentiation factor 15 (GDF-15), circulating Galactose Lectin 3 (Gal-3), soluble interleukin (sST2), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-α). For these biomarkers, the electrochemical biosensors have exhibited sufficient sensitivity, detection limit, and specificity. This review systematically summarizes the latest molecular biomarkers and sensors for heart failure, which will provide comprehensive and cutting-edge authoritative scientific information for biomedical and electronic-sensing researchers in the field of heart failure, as well as patients. In addition, our proposed future outlook may provide new research ideas for researchers.
心血管疾病（CVDs），特别是慢性心力衰竭，在全球范围内威胁着许多患者的生命。由于其病程缓慢且病因复杂，因此其临床筛查、诊断和预后是重要的挑战。临床生物标志物和生物传感器技术可以进行快速筛查和诊断。有多种类型的生物标志物可用于筛查、精确诊断和治疗随访。本文提供了与心力衰竭的六种主要病因途径相关的生物标志物的最新概述。血浆利钠肽（BNP 和 NT-proBNP）和心肌肌钙蛋白（cTnT、cTnl）仍然被分析为心力衰竭的金标准标志物。其他补充生物标志物包括生长分化因子 15（GDF-15）、循环半乳糖凝集素 3（Gal-3）、可溶性白细胞介素（sST2）、C 反应蛋白（CRP）和肿瘤坏死因子-α（TNF-α）。对于这些生物标志物，电化学生物传感器已表现出足够的灵敏度、检测限和特异性。本综述系统地总结了心力衰竭的最新分子生物标志物和传感器，为心力衰竭领域的生物医学和电子传感研究人员以及患者提供全面的、前沿的权威科学信息。此外，我们提出的未来展望可能为研究人员提供新的研究思路。
