Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, 150000, China.
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, 150000, China.
J Ethnopharmacol. 2024 Jun 28;328:118109. doi: 10.1016/j.jep.2024.118109. Epub 2024 Apr 1.
The Dryopteris crassirhizoma Nakai., a commonly used herb, is known as "Guan Zhong" in China, "Oshida" in Japan and "Gwanjung" in Korea. It has long been used for parasitic infestation, hemorrhages and epidemic influenza.
The present paper aims to provide an up-to-date review at the advancements of the investigations on the traditional use, phytochemistry, pharmacological activity, toxicology and pharmacokinetics of D. crassirhizoma. Besides, possible trends, therapeutic potentials, and perspectives for future research of this plant are also briefly discussed.
Relevant information on traditional use, phytochemistry, pharmacological activity, toxicology and pharmacokinetics of D. crassirhizoma was collected through published materials and electronic databases, including the Chinese Pharmacopoeia, Flora of China, Web of Science, PubMed, Baidu Scholar, Google Scholar, and China National Knowledge Infrastructure. 109 papers included in the article and we determined that no major information was missing after many checks. All authors participated in the review process for this article and all research paper are from authoritative published materials and electronic databases.
130 chemical components, among which phloroglucinols are the predominant groups, have been isolated and identified from D. crassirhizoma. D. crassirhizoma with its bioactive compounds is possessed of extensive biological activities, including anti-parasite, anti-microbial, anti-viral, anti-cancer, anti-inflammatory, anti-oxidant, anti-diabetic, bone protective, immunomodulatory, anti-platelet and anti-hyperuricemia activity. Besides, D. crassirhizoma has special toxicology and pharmacokinetics characterization.
D. crassirhizoma is a traditional Chinese medicine having a long history of application. This review mainly summarized the different chemical components extract from D. crassirhizoma and various reported pharmacological effects. Besides, the toxicology and pharmacokinetics of D. crassirhizoma also be analysed in this review. However, the chemical components of D. crassirhizoma are understudied and require further research to expand its medicinal potential, and it is urgent to design a new extraction scheme, so that the active ingredients can be obtained at a lower cost.
贯众，一种常用草药，在中国被称为“贯众”，在日本被称为“大野”，在韩国被称为“Gwanjung”。它一直被用于寄生虫感染、出血和流感流行。
本文旨在提供贯众的传统用途、植物化学、药理活性、毒理学和药代动力学研究进展的最新综述。此外，还简要讨论了该植物的可能趋势、治疗潜力和未来研究的前景。
通过出版材料和电子数据库，包括《中国药典》、《中国植物志》、Web of Science、PubMed、百度学者、谷歌学者和中国国家知识基础设施，收集了贯众的传统用途、植物化学、药理活性、毒理学和药代动力学的相关信息。文章共纳入 109 篇文献，经多次核对后确定没有重要信息遗漏。所有作者都参与了本文的评审过程，所有研究论文均来自权威出版材料和电子数据库。
从贯众中分离鉴定出 130 种化学成分，其中以苯丙素类化合物为主。含有生物活性化合物的贯众具有广泛的生物活性，包括抗寄生虫、抗微生物、抗病毒、抗癌、抗炎、抗氧化、抗糖尿病、护骨、免疫调节、抗血小板和抗高尿酸血症活性。此外，贯众具有特殊的毒理学和药代动力学特征。
贯众是一种历史悠久的中药。本综述主要总结了贯众不同的化学成分提取方法和各种报道的药理作用。此外，还分析了贯众的毒理学和药代动力学。然而，贯众的化学成分研究不足，需要进一步研究以扩大其药用潜力，急需设计新的提取方案，以便以更低的成本获得有效成分。
