Ohyashiki K, Oshimura M, Uchida H, Nomoto S, Sakai N, Tonomura A, Ito H
Cancer Genet Cytogenet. 1985 Jan 15;14(3-4):247-55. doi: 10.1016/0165-4608(85)90190-6.
Chromosomal banding analyses and ultrastructural studies were performed on ten cases of acute promyelocytic leukemia (APL-M3). A reciprocal translocation, t(15q + ;17q-), was found in six of them, and the possible breakpoints of these chromosomes were assigned at bands 15q22 and 17q12. In addition, trisomy 8, trisomy 8 and 21, and an isochromosome of the long arm of the translocated #17, i(17q-), were observed in addition to the 15;17 translocation in three cases, respectively. Furthermore, one patient was found to have a complex translocation in the marrow cells, i.e., 47,XX,+X,t(1p+;5q-;15q+;17q-). Ultrastructural studies demonstrated that the leukemic cells obtained from six of the seven patients with the chromosomal changes involving 17q12 and from two of the three with normal karyotypes contained stellate rough surface endoplasmic reticulum (stellate rER) complexes and/or inclusion bodies in part of the dilated rER.
对10例急性早幼粒细胞白血病（APL-M3）患者进行了染色体显带分析和超微结构研究。其中6例发现了相互易位，即t(15q + ;17q-)，这些染色体的可能断点定位于15q22和17q12带。此外，除3例分别存在15;17易位外，还观察到8号三体、8号和21号三体以及易位的17号染色体长臂等臂染色体，即i(17q-)。此外，1例患者骨髓细胞存在复杂易位，即47,XX,+X,t(1p+;5q-;15q+;17q-)。超微结构研究表明，7例染色体改变涉及17q12的患者中有6例以及3例核型正常的患者中有2例的白血病细胞，在部分扩张的粗面内质网（rER）中含有星状粗面内质网（星状rER）复合体和/或包涵体。
