Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, China.
Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.
Front Immunol. 2024 Mar 20;15:1347901. doi: 10.3389/fimmu.2024.1347901. eCollection 2024.
Most host-microbiota interactions occur within the intestinal barrier, which is essential for separating the intestinal epithelium from toxins, microorganisms, and antigens in the gut lumen. Gut inflammation allows pathogenic bacteria to enter the blood stream, forming immune complexes which may deposit on organs. Despite increased circulating immune complexes (CICs) in patients with inflammatory bowel disease (IBD) and discussions among IBD experts regarding their potential pathogenic role in extra-intestinal manifestations, this phenomenon is overlooked because definitive evidence demonstrating CIC-induced extra-intestinal manifestations in IBD animal models is lacking. However, clinical observations of elevated CICs in newly diagnosed, untreated patients with IBD have reignited research into their potential pathogenic implications. Musculoskeletal symptoms are the most prevalent extra-intestinal IBD manifestations. CICs are pivotal in various arthritis forms, including reactive, rheumatoid, and Lyme arthritis and systemic lupus erythematosus. Research indicates that intestinal barrier restoration during the pre-phase of arthritis could inhibit arthritis development. In the absence of animal models supporting extra-intestinal IBD manifestations, this paper aims to comprehensively explore the relationship between CICs and arthritis onset via a multifaceted analysis to offer a fresh perspective for further investigation and provide novel insights into the interplay between CICs and arthritis development in IBD.
大多数宿主-微生物群相互作用发生在肠道屏障内，肠道屏障对于将肠道上皮与肠道腔中的毒素、微生物和抗原分隔开至关重要。肠道炎症使致病菌能够进入血液，形成免疫复合物，这些复合物可能沉积在器官上。尽管炎症性肠病 (IBD) 患者的循环免疫复合物 (CIC) 增加，并且 IBD 专家就其在肠道外表现中的潜在致病作用进行了讨论，但由于缺乏明确的证据表明 CIC 诱导的 IBD 动物模型中的肠道外表现，这一现象被忽视了。然而，在新诊断的未经治疗的 IBD 患者中观察到 CIC 升高，这重新激发了对其潜在致病意义的研究。肌肉骨骼症状是最常见的肠道外 IBD 表现。CIC 在各种关节炎形式中起关键作用，包括反应性关节炎、类风湿关节炎和莱姆关节炎以及系统性红斑狼疮。研究表明，在关节炎的前期阶段进行肠道屏障修复可以抑制关节炎的发展。在缺乏支持肠道外 IBD 表现的动物模型的情况下，本文旨在通过多方面的分析全面探讨 CIC 与关节炎发病之间的关系，为进一步研究提供新的视角，并深入了解 IBD 中 CIC 与关节炎发展之间的相互作用。
