Yamamura T
J Dent Res. 1985 Apr;64 Spec No:530-40. doi: 10.1177/002203458506400406.
Based on recent literature, the dynamics of mesenchymal cells in transplantation of various tissues and matrices, as well as the origin of new odontoblasts which participate in the formation of the dentin bridge, are described. Experiments involving implantation of pulp, periosteum, perichondrium, treated dentin, and bone matrices were performed to emphasize the capability of these cells to produce hard tissue. Light and electron microscopic and autoradiographic studies were carried out to clarify the origin of replacement odontoblasts. It appears that the pulp cells, endothelial cells, and pericytes become undifferentiated mesenchymal cells following pulp exposure. These mesenchymal cells differentiate into odontoblasts, which subsequently produce a dentin matrix. Pulp tissues autografted to non-pulpal sites, elaborated bone (or osteodentin) matrix, but they did not graft to tubular dentin. An experiment on dentin bridge formation, using germ-free rats, demonstrated that the pulp tissue has intrinsic healing potential. Therefore, it was concluded that the ability of pulp tissue to elaborate hard tissues depends on its environment.
基于近期文献，描述了间充质细胞在各种组织和基质移植中的动态变化，以及参与牙本质桥形成的新成牙本质细胞的起源。进行了涉及植入牙髓、骨膜、软骨膜、处理过的牙本质和骨基质的实验，以强调这些细胞产生硬组织的能力。进行了光镜、电镜和放射自显影研究，以阐明替代成牙本质细胞的起源。牙髓暴露后，牙髓细胞、内皮细胞和周细胞似乎会变成未分化的间充质细胞。这些间充质细胞分化为成牙本质细胞，随后产生牙本质基质。自体移植到非牙髓部位的牙髓组织形成了骨（或骨样牙本质）基质，但它们并未形成管状牙本质。一项使用无菌大鼠进行的牙本质桥形成实验表明，牙髓组织具有内在的愈合潜力。因此，得出的结论是，牙髓组织形成硬组织的能力取决于其所处环境。
