The School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, 100084, China.
Laboratory of Sports Stress and Adaptation of General Administration of Sport, Beijing Sport University, Beijing, 100084, China.
Sci Rep. 2024 Apr 4;14(1):7933. doi: 10.1038/s41598-024-55925-6.
This study investigates the effects of a 12-week brisk walking exercise regimen on motor function improvements in elderly women. Twenty-six elderly women, aged 84.2 ± 3.2 years, participated in a 12-week brisk walking exercise program. Fitness assessments and blood biomarker analyses (including CHO, HDLC, LDLC, TC) were conducted pre- and post-intervention. Additionally, targeted metabolomics was employed to measure short-chain fatty acids, amino acids, and vitamin metabolites. The intervention led to significant enhancements in participants' flexibility (p < 0.05), lower limb muscle strength (p < 0.01), and cardiorespiratory endurance (p < 0.01), while muscle mass showed no significant changes. Fifteen significant differential metabolites were identified (VIP > 1.0, FC > 1.2 or < 0.8, and p < 0.05), with arginine, ornithine, aspartic acid, glutamine, phenylalanine, tyrosine, and pantothenic acid playing key roles across seven metabolic pathways. A 12-week brisk walking exercise program significantly enhanced flexibility, lower limb muscle strength, and cardiorespiratory endurance among elderly women. These improvements did not extend to muscle mass or upper limb muscle strength. The observed enhancement in exercise capacity may be attributed to improved regulation of neurotransmitters.
本研究旨在探究为期 12 周的快走运动方案对老年女性运动功能改善的影响。26 名年龄为 84.2±3.2 岁的老年女性参与了为期 12 周的快走运动方案。在干预前后进行了体能评估和血液生物标志物分析（包括 CHO、HDLC、LDLC、TC）。此外，还采用靶向代谢组学来测量短链脂肪酸、氨基酸和维生素代谢物。干预导致参与者的灵活性（p<0.05）、下肢肌肉力量（p<0.01）和心肺耐力（p<0.01）显著提高，而肌肉质量没有显著变化。鉴定出 15 个显著差异代谢物（VIP>1.0，FC>1.2 或<0.8，p<0.05），其中精氨酸、鸟氨酸、天冬氨酸、谷氨酰胺、苯丙氨酸、酪氨酸和泛酸在七个代谢途径中发挥关键作用。为期 12 周的快走运动方案显著提高了老年女性的灵活性、下肢肌肉力量和心肺耐力。这些改善并未延伸至肌肉质量或上肢肌肉力量。观察到的运动能力增强可能归因于神经递质调节的改善。
