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孟加拉国 SARS-CoV-2 病例的横断面家庭调查:COVID 后疼痛的临床表现及其对长期 COVID 患者生活质量的影响。

Clinical presentation of post-COVID pain and its impact on quality of life in long COVID patients: a cross-sectional household survey of SARS-CoV-2 cases in Bangladesh.

机构信息

Department of Rehabilitation Medicine, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, 88400, Kota Kinabalu, Sabah, Malaysia.

Department of Physiotherapy and Rehabilitation, Jashore University of Science and Technology (JUST), Jashore, Bangladesh.

出版信息

BMC Infect Dis. 2024 Apr 4;24(1):375. doi: 10.1186/s12879-024-09267-3.

DOI:10.1186/s12879-024-09267-3
PMID:38575878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10993502/
Abstract

BACKGROUND

Pain is one of the prevalent Long COVID Symptoms (LCS). Pain interferes with the quality of life (QoL) and induces disease burden.

PURPOSE

The study aimed to elicit the clinical presentation of pain and determine the relationships between QoL and pain in LCS.

METHODS

This household cross-sectional study of 12,925 SARS-CoV-2 cases between July and December 2021 was carried out in eight administrative divisions of Bangladesh. Stratified random sampling from the cases retrieved from the Ministry of Health was employed. Symptom screening was performed through COVID-19 Yorkshire Rehabilitation Scale, and long COVID was diagnosed according to World Health Organization (WHO) criteria. The analyses were conducted using IBM SPSS (Version 20.00).

RESULTS

The prevalence of pain in long COVID was between 01 and 3.1% in the studied population. The study also found five categories of pain symptoms as LCS in Bangladesh: muscle pain 3.1% (95% CI; 2.4-3.8), chest pain 2.4% (95% CI; 1.8-3.1), joint pain 2.8% (95% CI; 2.2-2.3), headache 3.1% (95% CI; 2.4-3.8), and abdominal pain 0.3% (95% CI; 0.01-0.5). People with LCS as pain, multiple LCS, and longer duration of LCS had significantly lower quality of life across all domains of the WHOQOL-BREF (P < 0.001) compared to asymptomatic cases.

CONCLUSION

Three out of ten people with long COVID experience painful symptoms, which can significantly reduce their quality of life. Comprehensive rehabilitation can improve the symptoms and reduce the burden of the disease.

摘要

背景

疼痛是常见的长新冠症状(LCS)之一。疼痛会干扰生活质量(QoL)并导致疾病负担。

目的

本研究旨在描述疼痛的临床表现,并确定 LCS 中 QoL 与疼痛之间的关系。

方法

本研究于 2021 年 7 月至 12 月在孟加拉国的 8 个行政区域内对 12925 例 SARS-CoV-2 病例进行了一项家庭横断面研究。采用分层随机抽样方法从卫生部获取病例。通过 COVID-19 约克郡康复量表进行症状筛查,并根据世界卫生组织(WHO)标准诊断长新冠。分析采用 IBM SPSS(版本 20.00)进行。

结果

在所研究的人群中,长新冠疼痛的患病率在 0.1%至 3.1%之间。研究还发现孟加拉国的长新冠疼痛有五类症状:肌肉疼痛 3.1%(95%CI;2.4-3.8)、胸痛 2.4%(95%CI;1.8-3.1)、关节痛 2.8%(95%CI;2.2-2.3)、头痛 3.1%(95%CI;2.4-3.8)和腹痛 0.3%(95%CI;0.01-0.5)。与无症状病例相比,有 LCS 疼痛、多种 LCS 和 LCS 持续时间较长的患者在 WHOQOL-BREF 的所有领域的生活质量明显较低(P < 0.001)。

结论

十分之三的长新冠患者经历疼痛症状,这会显著降低他们的生活质量。综合康复可以改善症状并减轻疾病负担。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/119a/10993502/69202647b1c9/12879_2024_9267_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/119a/10993502/05e794ac875c/12879_2024_9267_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/119a/10993502/9c4472c0aa15/12879_2024_9267_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/119a/10993502/d2da5e83b3d2/12879_2024_9267_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/119a/10993502/69202647b1c9/12879_2024_9267_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/119a/10993502/05e794ac875c/12879_2024_9267_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/119a/10993502/9c4472c0aa15/12879_2024_9267_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/119a/10993502/d2da5e83b3d2/12879_2024_9267_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/119a/10993502/69202647b1c9/12879_2024_9267_Fig4_HTML.jpg

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本文引用的文献

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Arch Public Health. 2023 Jul 17;81(1):132. doi: 10.1186/s13690-023-01140-0.
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多中心学术机构中长新冠的重叠病症
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BMC Infect Dis. 2024 Sep 19;24(1):1001. doi: 10.1186/s12879-024-09896-8.
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