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对于某些麻风反应患者，是否应考虑预防性治疗耶氏肺孢子菌肺炎？

Should prophylaxis against Pneumocystis jirovecii pneumonia be considered in selected patients with leprosy reactions?

作者信息

Ramírez-Perea Nuria, Moran-Castaño Claudia, Perez-Molina Jose A

机构信息

Internal Medicine Department, Elda University Hospital, Alicante, 03600, Spain.

Internal Medicine Department, Carmen y Severo Ochoa Hospital, Asturias, Spain.

出版信息

Pneumonia (Nathan). 2024 Apr 5;16(1):6. doi: 10.1186/s41479-024-00127-x.

DOI:10.1186/s41479-024-00127-x
PMID:38576014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10996082/
Abstract

Leprosy reactions often require prolonged high-dose steroids or immunosuppressive drugs, putting patients at risk of Pneumocystis jirovecii pneumonia (PJP). However, no PJP cases are reported, possibly due to dapsone treatment for leprosy. In patients with leprosy reactions not receiving dapsone because of toxicity or resistance and requiring long-term immunosuppression, PJP prophylaxis should be considered.

摘要

麻风反应通常需要长期使用大剂量类固醇或免疫抑制药物，这使患者有患耶氏肺孢子菌肺炎（PJP）的风险。然而，尚未有PJP病例的报告，这可能归因于麻风病的氨苯砜治疗。对于因毒性或耐药性未接受氨苯砜治疗且需要长期免疫抑制的麻风反应患者，应考虑进行PJP预防。

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