Long Jiaye, Yang Miyang, Pang Yingrong, Kang Hongyan, Liang Shuai, Wang Du
Department of Interventional Radiology, Inner Mongolia Forestry General Hospital, The Second Clinical Medical School of Inner Mongolia University for The Nationalities, Yakeshi, Inner Mongolia, China.
Department of Radiology, The First Clinical Medical College, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
Front Oncol. 2024 Mar 21;14:1366958. doi: 10.3389/fonc.2024.1366958. eCollection 2024.
Although observational studies suggest a correlation between psoriasis (PS) and cancers, it is still unknown whether this association can replace causal relationships due to the limitations of observational studies. Therefore, we conducted a two-sample Mendelian randomization (MR) analysis to evaluate the causal relationship between PS and cancers.
PS genetic summary data were obtained from two genome-wide association studies (GWAS). We employed MR Base for individuals retrieving tumors from distinct locations. Inverse-variance weighted analysis was the principal method used for MR, supplemented by weighted median, MR Egger, simple mode, and weighted mode. To investigate the possible link between psoriasis and cancers, we performed two independent two-sample MR studies and a meta-analysis based on two independent MR analyses.
Two independent MR analyses both found no significant causal relationship between PS and overall cancers (OR=1.0000, 95% confidence interval [CI]:0.9999-1.0001, =0.984; OR=1.0000, 95% CI:0.9999-1.0001, =0.761), and no significant causal relationship with 17 site-specific cancers. In the meta-analysis conducted by two two-sample MR analyses, there was no significant causal relationship between PS and overall cancers (OR=1.0000, 95% CI: 0.9999-1.0001, =1.00, 0.0%), and there was no significant causal relationship with 17 site-specific cancers.
Our findings do not support a genetic link between PS and cancers. More population-based and experimental investigations will be required better to understand the complicated relationship between PS and cancers.
尽管观察性研究表明银屑病（PS）与癌症之间存在关联，但由于观察性研究的局限性，这种关联是否能代表因果关系仍不明确。因此，我们进行了一项两样本孟德尔随机化（MR）分析，以评估PS与癌症之间的因果关系。
PS基因汇总数据来自两项全基因组关联研究（GWAS）。我们利用MR Base获取来自不同部位肿瘤患者的个体数据。逆方差加权分析是MR的主要方法，辅以加权中位数、MR Egger、简单模式和加权模式。为了研究银屑病与癌症之间可能的联系，我们进行了两项独立的两样本MR研究，并基于两项独立的MR分析进行了荟萃分析。
两项独立的MR分析均未发现PS与总体癌症之间存在显著因果关系（比值比[OR]=1.0000，95%置信区间[CI]：0.9999 - 1.0001，P=0.984；OR=1.0000，95%CI：0.9999 - 1.0001，P=0.761），与17种特定部位癌症也无显著因果关系。在两项两样本MR分析的荟萃分析中，PS与总体癌症之间无显著因果关系（OR=1.0000，95%CI：0.9999 - 1.0001，P=1.00，I²=0.0%），与17种特定部位癌症也无显著因果关系。
我们的研究结果不支持PS与癌症之间存在遗传联系。需要更多基于人群的研究和实验性研究，以更好地理解PS与癌症之间的复杂关系。
