• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

调节性 T 细胞在小鼠肺发育中的作用。

Role of regulatory T cells in mouse lung development.

机构信息

Department of Pediatrics, Affiliated Hospital of Jiangsu University, Zhenjiang, China.

出版信息

Exp Biol Med (Maywood). 2024 Mar 21;249:10040. doi: 10.3389/ebm.2024.10040. eCollection 2024.

DOI:10.3389/ebm.2024.10040
PMID:38577707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10991720/
Abstract

Regulatory T cells (Tregs) constitute a specialized subset of T cells with dual immunoregulatory and modulatory functions. Recent studies have reported that Tregs mediate immune responses and regulate the development and repair processes in non-lymphoid tissues, including bone and cardiac muscle. Additionally, Tregs facilitate the repair and regeneration of damaged lung tissues. However, limited studies have examined the role of Tregs in pulmonary development. This study aimed to evaluate the role of Tregs in pulmonary development by investigating the dynamic alterations in Tregs and their hallmark cellular factor Forkhead box P3 (Foxp3) at various stages of murine lung development and establishing a murine model of anti-CD25 antibody-induced Treg depletion. During the early stages of murine lung development, especially the canalicular and saccular stages, the levels of Treg abundance and expression of Foxp3 and transforming growth factor-β (TGF-β) were upregulated. This coincided with the proliferation period of alveolar epithelial cells and vascular endothelial cells, indicating an adaptation to the dynamic lung developmental processes. Furthermore, the depletion of Tregs disrupted lung tissue morphology and downregulated lung development-related factors, such as surfactant protein C (SFTPC), vascular endothelial growth factor A (VEGFA) and platelet endothelial cell adhesion molecule-1 (PECAM1/CD31). These findings suggest that Tregs promote murine lung development.

摘要

调节性 T 细胞（Tregs）是具有双重免疫调节和调节功能的 T 细胞的一个特殊亚群。最近的研究报告称，Tregs 介导免疫反应，并调节非淋巴组织（包括骨骼和心肌）的发育和修复过程。此外，Tregs 有助于受损肺组织的修复和再生。然而，关于 Tregs 在肺发育中的作用的研究有限。本研究旨在通过研究 Tregs 及其标志性细胞因子叉头框 P3（Foxp3）在小鼠肺发育的各个阶段的动态变化，并建立抗 CD25 抗体诱导 Treg 耗竭的小鼠模型，来评估 Tregs 在肺发育中的作用。在小鼠肺发育的早期阶段，特别是在小管和囊泡阶段，Treg 丰度的水平和 Foxp3 和转化生长因子-β（TGF-β）的表达上调。这与肺泡上皮细胞和血管内皮细胞的增殖期相吻合，表明其适应了动态的肺发育过程。此外，Treg 的耗竭破坏了肺组织形态，并下调了与肺发育相关的因子，如表面活性剂蛋白 C（SFTPC）、血管内皮生长因子 A（VEGFA）和血小板内皮细胞黏附分子-1（PECAM1/CD31）。这些发现表明 Tregs 促进了小鼠肺的发育。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a1c/10991720/c2ef0f9cda93/ebm-249-10040-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a1c/10991720/4976b2f0f7f0/ebm-249-10040-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a1c/10991720/9bfd34f37160/ebm-249-10040-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a1c/10991720/5e6b49c37759/ebm-249-10040-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a1c/10991720/99b650d11ddd/ebm-249-10040-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a1c/10991720/1e8e990e3d3c/ebm-249-10040-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a1c/10991720/c2ef0f9cda93/ebm-249-10040-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a1c/10991720/4976b2f0f7f0/ebm-249-10040-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a1c/10991720/9bfd34f37160/ebm-249-10040-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a1c/10991720/5e6b49c37759/ebm-249-10040-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a1c/10991720/99b650d11ddd/ebm-249-10040-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a1c/10991720/1e8e990e3d3c/ebm-249-10040-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a1c/10991720/c2ef0f9cda93/ebm-249-10040-g006.jpg

相似文献

1
Role of regulatory T cells in mouse lung development.调节性 T 细胞在小鼠肺发育中的作用。
Exp Biol Med (Maywood). 2024 Mar 21;249:10040. doi: 10.3389/ebm.2024.10040. eCollection 2024.
2
IRF4 affects the protective effect of regulatory T cells on the pulmonary vasculature of a bronchopulmonary dysplasia mouse model by regulating FOXP3.IRF4 通过调控 FOXP3 影响调节性 T 细胞对支气管肺发育不良小鼠模型肺血管的保护作用。
Mol Med. 2024 Jan 9;30(1):6. doi: 10.1186/s10020-023-00770-y.
3
Promoted Generation of T Helper 1-Like Regulatory T Cells After Transient Middle Cerebral Artery Occlusion in Type-2 Diabetic Mice.2 型糖尿病小鼠短暂性大脑中动脉闭塞后 T 辅助 1 样调节性 T 细胞的促进生成。
Immunol Invest. 2023 Nov;52(4):482-498. doi: 10.1080/08820139.2023.2197009. Epub 2023 Apr 19.
4
Methionine enkephalin (MENK) inhibits tumor growth through regulating CD4+Foxp3+ regulatory T cells (Tregs) in mice.甲硫氨酸脑啡肽（MENK）通过调节小鼠体内的CD4+Foxp3+调节性T细胞（Tregs）来抑制肿瘤生长。
Cancer Biol Ther. 2015;16(3):450-9. doi: 10.1080/15384047.2014.1003006.
5
Helios expression in regulatory T cells promotes immunosuppression, angiogenesis and the growth of leukemia cells in pediatric acute lymphoblastic leukemia.调节性T细胞中Helios的表达促进小儿急性淋巴细胞白血病中的免疫抑制、血管生成和白血病细胞生长。
Leuk Res. 2018 Apr;67:60-66. doi: 10.1016/j.leukres.2018.02.007. Epub 2018 Feb 14.
6
The Role of mPGES-1 in Promoting Granulation Tissue Angiogenesis Through Regulatory T-cell Accumulation.mPGES-1 通过调节性 T 细胞聚集促进肉芽组织血管生成的作用。
In Vivo. 2022 Sep-Oct;36(5):2061-2073. doi: 10.21873/invivo.12932.
7
Foxp3 Regulatory T Cell Expression of Keratinocyte Growth Factor Enhances Lung Epithelial Proliferation.角质形成细胞生长因子的Foxp3调节性T细胞表达增强肺上皮细胞增殖。
Am J Respir Cell Mol Biol. 2017 Aug;57(2):162-173. doi: 10.1165/rcmb.2017-0019OC.
8
Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4CD25Foxp3 and CD4CD25Foxp3 T cells.阻断 TGF-β 信号转导增强抗肿瘤反应的同时，也伴随着 CD4CD25Foxp3 和 CD4CD25Foxp3 T 细胞功能活性的失调。
J Transl Med. 2019 Jul 9;17(1):219. doi: 10.1186/s12967-019-1967-3.
9
TGF-β-dependent induction of CD4⁺CD25⁺Foxp3⁺ Tregs by liver sinusoidal endothelial cells.肝窦内皮细胞通过 TGF-β 依赖性诱导产生 CD4⁺CD25⁺Foxp3⁺Tregs。
J Hepatol. 2014 Sep;61(3):594-9. doi: 10.1016/j.jhep.2014.04.027. Epub 2014 May 2.
10
The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors.白细胞介素4受体α链结合细胞因子白细胞介素4和白细胞介素13可从CD25-CD4+前体细胞诱导出表达叉头框P3的CD25+CD4+调节性T细胞。
J Immunol. 2005 Nov 1;175(9):6107-16. doi: 10.4049/jimmunol.175.9.6107.

本文引用的文献

1
Lung development and regeneration: newly defined cell types and progenitor status.肺的发育与再生：新定义的细胞类型和祖细胞状态。
Cell Regen. 2023 Apr 3;12(1):5. doi: 10.1186/s13619-022-00149-0.
2
Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity.IL-2 与 IL-2Rα 的临近效应共价结合，选择性地激活调节性 T 细胞并抑制自身免疫。
Signal Transduct Target Ther. 2023 Jan 23;8(1):28. doi: 10.1038/s41392-022-01208-3.
3
Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells.
遗传示踪揭示了外周诱导的 Treg 细胞中转录因子 Foxp3 依赖性和 Foxp3 非依赖性的功能。
Immunity. 2022 Jul 12;55(7):1173-1184.e7. doi: 10.1016/j.immuni.2022.05.010. Epub 2022 Jun 13.
4
Transforming growth factor-β1 in regulatory T cell biology.转化生长因子-β1 在调节性 T 细胞生物学中的作用。
Sci Immunol. 2022 Mar 18;7(69):eabi4613. doi: 10.1126/sciimmunol.abi4613.
5
Developmental Pathways Underlying Lung Development and Congenital Lung Disorders.肺发育和先天性肺疾病的发育途径。
Cells. 2021 Nov 2;10(11):2987. doi: 10.3390/cells10112987.
6
The History and Mystery of Alveolar Epithelial Type II Cells: Focus on Their Physiologic and Pathologic Role in Lung.肺泡 II 型上皮细胞的历史与奥秘：聚焦其在肺部的生理与病理作用。
Int J Mol Sci. 2021 Mar 4;22(5):2566. doi: 10.3390/ijms22052566.
7
Effect of low VEGF on lung development and function.低 VEGF 对肺发育和功能的影响。
Transgenic Res. 2021 Feb;30(1):35-50. doi: 10.1007/s11248-020-00223-w. Epub 2021 Jan 4.
8
Regulatory T Cells in Angiogenesis.调节性 T 细胞与血管生成。
J Immunol. 2020 Nov 15;205(10):2557-2565. doi: 10.4049/jimmunol.2000574.
9
mTOR signaling at the crossroads of environmental signals and T-cell fate decisions.mTOR 信号在环境信号和 T 细胞命运决定的十字路口。
Immunol Rev. 2020 May;295(1):15-38. doi: 10.1111/imr.12845. Epub 2020 Mar 25.
10
Comprehensive anatomic ontologies for lung development: A comparison of alveolar formation and maturation within mouse and human lung.用于肺发育的综合解剖本体论：小鼠和人肺内肺泡形成与成熟的比较
J Biomed Semantics. 2019 Oct 24;10(1):18. doi: 10.1186/s13326-019-0209-1.