Meng Xiaogao, Cui Guizhong, Peng Guangdun
Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, Guangdong, China.
Life Science and Medicine, University of Science and Technology of China, Hefei, 230026, Anhui, China.
Cell Regen. 2023 Apr 3;12(1):5. doi: 10.1186/s13619-022-00149-0.
The lung is the most critical organ of the respiratory system supporting gas exchange. Constant interaction with the external environment makes the lung vulnerable to injury. Thus, a deeper understanding of cellular and molecular processes underlying lung development programs and evaluation of progenitor status within the lung is an essential part of lung regenerative medicine. In this review, we aim to discuss the current understanding of lung development process and regenerative capability. We highlight the advances brought by multi-omics approaches, single-cell transcriptome, in particular, that can help us further dissect the cellular player and molecular signaling underlying those processes.
肺是支持气体交换的呼吸系统中最关键的器官。与外部环境的持续相互作用使肺容易受到损伤。因此，深入了解肺发育程序背后的细胞和分子过程以及评估肺内祖细胞状态是肺再生医学的重要组成部分。在这篇综述中，我们旨在讨论对肺发育过程和再生能力的当前理解。我们强调了多组学方法，特别是单细胞转录组学带来的进展，这些进展可以帮助我们进一步剖析这些过程背后的细胞参与者和分子信号传导。
