College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Beijing 100193, China; Laboratory of Key Technologies of Major Comprehensive Guarantee of Food Safety for State Market Regulation, Beijing Institute of Food Inspection and Research (Beijing Municipal Center for Food Safety Monitoring and Risk Assessment), Beijing, 100094, China.
Laboratory of Key Technologies of Major Comprehensive Guarantee of Food Safety for State Market Regulation, Beijing Institute of Food Inspection and Research (Beijing Municipal Center for Food Safety Monitoring and Risk Assessment), Beijing, 100094, China.
Food Chem. 2024 Aug 1;448:139144. doi: 10.1016/j.foodchem.2024.139144. Epub 2024 Mar 31.
Tris(2,4-di-tert-butylphenyl) phosphite (AO168), an organophosphite antioxidant, can be oxidized to tris(2,4-di-tert-butylphenyl) phosphate (AO168 = O) during the production, processing, and application of plastics. AO168 = O can be further transformed to bis(2,4-di-tert-butylphenyl) phosphate and 2,4-di-tert-butylphenol. Here, we discovered the contamination of AO168 and its transformation products in dairy products for the first time. More samples contained AO168 (mean concentration: 8.78 ng/g wet weight [ww]), bis(2,4-di-tert-butylphenyl) phosphate (mean:11.1 ng/g ww) and 2,4-di-tert-butylphenol (mean: 46.8 ng/g ww) than AO168 = O (mean: 40.2 ng/g ww). The concentrations of AO168 and its transformation products were significantly correlated, and differed with the packaging material and storage conditions of the product. Estimated daily intakes (EDIs) of AO168 and its transformation products were calculated. Although the overall dietary risks were below one, transformation products accounted for 96.7% of the total hazard quotients. The high-exposure EDIs of total AO168 were above the threshold of toxicological concern (300 ng/kg bw/day), and deserve continual monitoring.
三（2,4-二叔丁基苯基）亚磷酸酯（AO168）是一种有机亚磷酸酯抗氧化剂，在塑料的生产、加工和应用过程中，可能会被氧化为三（2,4-二叔丁基苯基）磷酸酯（AO168=O）。AO168=O 可以进一步转化为双（2,4-二叔丁基苯基）磷酸酯和 2,4-二叔丁基苯酚。在这里，我们首次发现了乳制品中 AO168 及其转化产物的污染。更多的样品含有 AO168（平均浓度：8.78ng/g 湿重[ww]）、双（2,4-二叔丁基苯基）磷酸酯（平均：11.1ng/g ww）和 2,4-二叔丁基苯酚（平均：46.8ng/g ww），而 AO168=O（平均：40.2ng/g ww）。AO168 及其转化产物的浓度呈显著正相关，且与产品的包装材料和储存条件有关。计算了 AO168 及其转化产物的估计每日摄入量（EDI）。尽管总的饮食风险低于 1，但转化产物占总危害系数的 96.7%。总 AO168 的高暴露 EDI 高于毒理学关注阈值（300ng/kg bw/day），值得持续监测。
