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Covalent conjugation of AZD8055 with unsaturated fatty acids for the development of mTOR nanoblockers: increasing the therapeutic efficacy of hepatocellular carcinoma treatment.

作者信息

Chau Wing Ki, Lee Terence Kin Wah

机构信息

Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.

Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong; State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong.

出版信息

EBioMedicine. 2024 May;103:105113. doi: 10.1016/j.ebiom.2024.105113. Epub 2024 Apr 6.

DOI:10.1016/j.ebiom.2024.105113
PMID:38583261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11002569/
Abstract
摘要

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Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy.化学工程化 mTOR 纳米颗粒阻滞剂增强抗肿瘤疗效。
EBioMedicine. 2024 May;103:105099. doi: 10.1016/j.ebiom.2024.105099. Epub 2024 Apr 10.
2
Heterogeneity of hepatocellular carcinoma: from mechanisms to clinical implications.肝细胞癌的异质性：从机制到临床意义。
Cancer Gene Ther. 2024 Aug;31(8):1105-1112. doi: 10.1038/s41417-024-00764-w. Epub 2024 Mar 18.
3
T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma.T 细胞耗竭和驻留动力学为肝细胞癌的临床结局提供信息。
J Hepatol. 2022 Aug;77(2):397-409. doi: 10.1016/j.jhep.2022.02.032. Epub 2022 Apr 1.
4
Albumin-based nanostructures for uveal melanoma treatment.基于白蛋白的纳米结构用于葡萄膜黑色素瘤的治疗。
Nanomedicine. 2021 Jul;35:102391. doi: 10.1016/j.nano.2021.102391. Epub 2021 Mar 29.
5
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020：全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
6
mTOR signalling and cellular metabolism are mutual determinants in cancer.mTOR 信号和细胞代谢在癌症中是相互决定因素。
Nat Rev Cancer. 2018 Dec;18(12):744-757. doi: 10.1038/s41568-018-0074-8.
7
Molecular therapies and precision medicine for hepatocellular carcinoma.肝细胞癌的分子治疗和精准医学。
Nat Rev Clin Oncol. 2018 Oct;15(10):599-616. doi: 10.1038/s41571-018-0073-4.
8
Supramolecular nanoparticles that target phosphoinositide-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy.靶向磷酸肌醇-3-激酶的超分子纳米颗粒克服胰岛素抵抗并发挥显著的抗肿瘤疗效。
Cancer Res. 2013 Dec 1;73(23):6987-97. doi: 10.1158/0008-5472.CAN-12-4477. Epub 2013 Oct 11.
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Br J Cancer. 2012 Sep 25;107(7):1093-9. doi: 10.1038/bjc.2012.368. Epub 2012 Aug 30.
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