Greig Jenny, Delfino Giada, Derkinderen Pascal, Paillusson Sébastien
INSERM, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France.
Nantes Université, INSERM, CHU Nantes, The Enteric Nervous System in Gut and Brain Disorders, Nantes, France.
Contact (Thousand Oaks). 2024 Apr 4;7:25152564241244941. doi: 10.1177/25152564241244941. eCollection 2024 Jan-Dec.
Changes in the connections between the endoplasmic reticulum (ER) and mitochondria, as well as alterations in mitochondria-associated ER membrane (MAM) signalling, have been documented in various neurodegenerative diseases affecting the brain. Despite the growing recognition of the significance of the gut-brain axis in neurodegenerative conditions, there has been no prior investigation into the biology of MAM within the enteric nervous system (ENS). Our recent research reveals, for the first time, the existence of connections between the ER and mitochondria within enteric neurons. Additionally, we observed alterations in the dynamics of these connections in the enteric neurons from a mouse model exhibiting age-related neurodegeneration. These findings provide the first detailed characterization of MAM in the ENS under physiological conditions and in a mouse model of age-associated neurodegeneration and shed new light on the potential role of enteric MAM in the context of neurodegenerative disorders.
内质网（ER）与线粒体之间连接的变化，以及线粒体相关内质网膜（MAM）信号传导的改变，已在多种影响大脑的神经退行性疾病中得到记录。尽管人们越来越认识到肠-脑轴在神经退行性疾病中的重要性，但此前尚未对肠神经系统（ENS）内MAM的生物学特性进行过研究。我们最近的研究首次揭示了肠神经元内ER与线粒体之间存在连接。此外，我们在一个表现出与年龄相关神经退行性变的小鼠模型的肠神经元中观察到这些连接动态的改变。这些发现首次详细描述了生理条件下以及年龄相关神经退行性变小鼠模型中ENS内的MAM，并为肠MAM在神经退行性疾病中的潜在作用提供了新的线索。
