Pollard M, Luckert P H
J Natl Cancer Inst. 1985 Jun;74(6):1347-9.
The influence of diet restriction on induction of intestinal tumors in Sprague-Dawley rats by two unique carcinogenic agents was investigated: methylazoxymethanol acetate [(MAM) CAS: 592-62-1], which requires metabolic activation, and N-methylnitrosourea [(MNU) CAS: 684-93-5], which is a direct-acting carcinogen. Most of the tumors induced by MAM developed in the small intestine and less frequently in the colon, but MNU produced tumors predominantly in the colon. Among rats fed the restricted diet (12 g/day), the production of tumors by MAM was significantly reduced compared to that of counterpart rats on the ad libitum diet. However, dietary restriction did not modify the production of tumors in rats by MNU. The same relationship of diet restriction to tumor induction was demonstrable when MAM and MNU were administered to the same test rats: Numbers of MAM-related tumors, especially in the small intestine, were reduced and numbers of MNU-related tumors in the colon were unchanged. Dietary restriction modified the tumorigenic response of rats to MAM but not to MNU.
研究了饮食限制对两种独特致癌剂诱导斯普拉格-道利大鼠肠道肿瘤的影响：需要代谢激活的乙酸甲基偶氮甲醇[（MAM），化学物质登记号：592-62-1]和直接作用致癌物N-甲基亚硝基脲[（MNU），化学物质登记号：684-93-5]。MAM诱导的大多数肿瘤发生在小肠，在结肠中较少见，但MNU诱导的肿瘤主要发生在结肠。在喂食限制饮食（每天12克）的大鼠中，与自由采食饮食的对照大鼠相比，MAM诱导的肿瘤发生率显著降低。然而，饮食限制并未改变MNU诱导大鼠肿瘤的发生率。当将MAM和MNU给予同一批受试大鼠时，饮食限制与肿瘤诱导之间的相同关系是可证明的：与MAM相关的肿瘤数量，尤其是小肠中的肿瘤数量减少，而结肠中与MNU相关的肿瘤数量未变。饮食限制改变了大鼠对MAM的致瘤反应，但未改变对MNU的致瘤反应。
