Pollard M, Luckert P H, Pan G Y
Cancer Treat Rep. 1984 Feb;68(2):405-8.
Male Sprague-Dawley rats were inoculated once with methylazoxymethanol (MAM) and groups were fed restricted diets for the following 140 days: Group A or B was fed a 12-g diet daily (25% restricted) from Day 10 or Day 63 after MAM, respectively. Group C or D was fed ad libitum only every other day from Day 8 or Day 31 after MAM, respectively. Control MAM-treated rats were fed the same diet ad libitum. When examined at Day 140, there was a significant reduction of intestinal tumors in Group A on the restricted diet from Day 10; however, among all other groups there were no significant differences in tumor incidences. Later onset of daily dietary restriction or of feeding and fasting every other day did not change the pattern of tumorigenesis from that which developed in control rats fed ad libitum.
雄性斯普拉格-道利大鼠一次性接种甲基氧化偶氮甲醇（MAM），随后将大鼠分为几组，并在接下来的140天给予限制饮食：A组或B组分别在接种MAM后的第10天或第63天开始，每天喂食12克食物（限制25%）。C组或D组分别在接种MAM后的第8天或第31天开始，每隔一天自由进食一次。接受MAM处理的对照大鼠自由进食相同的食物。在第140天检查时，从第10天开始接受限制饮食的A组肠道肿瘤显著减少；然而，在所有其他组中，肿瘤发生率没有显著差异。每日饮食限制或隔日喂食和禁食的较晚开始并没有改变从自由进食的对照大鼠所发生的肿瘤发生模式。
