Pharmacy Department, Liyuan Hospital, Huazhong University of Science and Technology, Wuhan, 430077, People's Republic of China.
Department of Ophthalmology, Liyuan Hospital, Huazhong University of Science and Technology, Wuhan, 430077, People's Republic of China.
Int Ophthalmol. 2024 Apr 8;44(1):170. doi: 10.1007/s10792-024-03098-6.
Diabetic retinopathy and stroke are both vascular pathologies, and this study intends to investigate the relationship between diabetic retinopathy and stroke.
The NHANES database was used to find the relationship between diabetic retinopathy and stroke with 1948 individuals aged 40 years or older. The sensitivity of the data was verified by multiple interpolation, further analysis was done by subgroup analyses, and possible links were investigated with mediation studies.
Diabetes retinopathy was found to be closely associated with stroke, with the PDR group having a higher stroke incidence than the NPDR group. After controlling for covariates, there were still substantial differences in the risk of stroke among patients with NPDR and PDR. Overall, subgroup analysis revealed DR group showed an important distinction, compared to the non-DR (OR = 1.76, 95% CI 1.15-2.64). The results of the mediation research indicated that the connection between DR and stroke was mediated by the frailty index and hypertension.
This study demonstrated a statistically significant correlation between DR and stroke, which persisted even after DR staging and was more prevalent in PDR patients than in NPDR patients. Stroke prevention may benefit from DR health management.
糖尿病视网膜病变和中风都是血管病变，本研究旨在探讨糖尿病视网膜病变与中风之间的关系。
本研究使用 NHANES 数据库，纳入了 1948 名年龄在 40 岁及以上的个体，来寻找糖尿病视网膜病变与中风之间的关系。通过多次插值验证数据的敏感性，进一步通过亚组分析进行分析，并通过中介研究来探索可能的联系。
糖尿病视网膜病变与中风密切相关，PDR 组的中风发生率高于 NPDR 组。在控制了协变量后，NPDR 和 PDR 患者的中风风险仍存在显著差异。总体而言，亚组分析显示，DR 组与非 DR 组相比有显著差异（OR=1.76，95%CI 1.15-2.64）。中介研究的结果表明，DR 和中风之间的联系是由脆弱指数和高血压介导的。
本研究表明 DR 和中风之间存在统计学上显著的相关性，这种相关性在 DR 分期后仍然存在，并且在 PDR 患者中比 NPDR 患者更为普遍。中风的预防可能受益于 DR 的健康管理。
