Department of Mental Health, Graduate School of Medicine, The University of Tokyo, Bunkyo, Japan.
Department of Social Medicine, National Center for Child Health and Development, Setagaya, Japan.
Arch Womens Ment Health. 2024 Oct;27(5):827-836. doi: 10.1007/s00737-024-01463-z. Epub 2024 Apr 9.
Perinatal mood disorders affect both parents, impacting their children negatively. Little is known on the association between parental perinatal mood disorders and pediatric outcomes in Japan considering relevant covariates. Our objective was to investigate the association between paternal and maternal perinatal mood disorders and adverse physical and psychological child outcomes by the age of 36 months, adjusting for covariates such as the child's sex, age of parent at child's birth, perinatal mood disorders of the other parent, and perinatal antidepressant use.
We identified parents in the JMDC Claims Database in Japan from 2012 to 2020. Perinatal mood disorders were defined using International Classification of Diseases, 10th codes for mood disorders during the perinatal period combined with psychiatric treatment codes. We evaluated the association between parental perinatal mood disorders and pediatric adverse outcomes by the age of 36 months using Cox proportional hazard models adjusted for the covariates.
Of the 116,423 father-mother-child triads, 2.8% of fathers and 2.3% of mothers had perinatal mood disorders. Paternal perinatal mood disorders were not significantly associated with adverse child outcomes. After adjusting for paternal perinatal mood disorders and antidepressant use, maternal perinatal mood disorders were associated with delayed motor development, language development disorders, autism spectrum disorders, and behavioral and emotional disorders (adjusted hazard ratio [95% confidence interval]: 1.65 [1.01-2.69], 2.26 [1.36-3.75], 4.16 [2.64-6.55], and 6.12 [1.35-27.81], respectively).
Paternal perinatal mood disorders were not associated with adverse child outcomes in this population. Maternal perinatal mood disorders were associated with multiple child outcomes.
围产期情绪障碍会影响父母双方，对其子女产生负面影响。在考虑相关协变量的情况下，日本围产期情绪障碍与儿科结局之间的关联知之甚少。我们的目的是调查围产期情绪障碍父亲和母亲与 36 个月龄时儿童不良身体和心理结局之间的关联，调整协变量，如儿童的性别、父母生育时的年龄、另一位父母的围产期情绪障碍以及围产期抗抑郁药的使用。
我们从 2012 年至 2020 年在日本 JMDC 理赔数据库中确定了父母。围产期情绪障碍使用国际疾病分类，第 10 版围产期期间的情绪障碍代码与精神科治疗代码相结合进行定义。我们使用 Cox 比例风险模型评估了调整协变量后，父母围产期情绪障碍与 36 个月龄时儿科不良结局之间的关联。
在 116423 个父亲-母亲-儿童三对一组中，2.8%的父亲和 2.3%的母亲患有围产期情绪障碍。父亲的围产期情绪障碍与儿童不良结局无显著关联。在调整了父亲的围产期情绪障碍和抗抑郁药使用后，母亲的围产期情绪障碍与运动发育迟缓、语言发育障碍、自闭症谱系障碍和行为和情绪障碍相关（调整后的危险比[95%置信区间]：1.65[1.01-2.69]、2.26[1.36-3.75]、4.16[2.64-6.55]和 6.12[1.35-27.81]）。
在本研究人群中，父亲的围产期情绪障碍与儿童不良结局无关。母亲的围产期情绪障碍与多种儿童结局相关。
