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不同抗生素药物对微生物的比较:一项原创研究。

Comparison of Different Antibiotic Medications on Microorganisms: An Original Research.

作者信息

Patil Ruthika S, Onteru Pradeep, Jena Janmajay, Shashank Chapala, Siddiqua Humera, Parikh Hiral A, Tiwari Heena Dixit

机构信息

Prosthodontics, Research Student Worker, Kornberg School of Dentistry, Temple University, Philadelphia, United States.

Department of Public Health Dentistry, Father Colombo Institute of Medical Sciences, Warangal, Telangana, India.

出版信息

J Pharm Bioallied Sci. 2024 Feb;16(Suppl 1):S223-S226. doi: 10.4103/jpbs.jpbs_471_23. Epub 2024 Feb 29.

DOI:10.4103/jpbs.jpbs_471_23
PMID:38595449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11001070/
Abstract

INTRODUCTION

The onset and maintenance of disease can be significantly influenced by the colonization of the mouth cavity by pathogenic microorganisms or by an imbalance of the physiological microbiome. Hence, in the current study, various commonly used antibiotics have been tested for their antibacterial and antifungal activity.

MATERIALS AND METHODS

The current research was performed as an study. The commonly used antibiotics Augmentin (CV), Ceftriaxone-Cephalosporin (CF), and Linezolid were tested for the microorganisms, lactobacillus, and . The "Radius of Zone of Inhibition (mm)- RZI" after 24 and 48 h were tested by the agar-well diffusion method.

RESULTS

For , the antibiotics tested were CV (5 μl and 2.5 μl), CF (5 μl and 2.5 μl), and Linezolid (5 μl and 2.5 μl). The results showed that the radius of the zone of inhibition was consistent for each antibiotic concentration, with a range of 0.8-1.4 mm at both time points. For Lactobacillus, the antibiotics tested were CV (5 μl and 2.5 μl), CF (5 μl and 2.5 μl), and Linezolid (5 μl and 2.5 μl). The results showed that the radius of the zone of inhibition varied between antibiotics and concentrations, with a range of 0.5-1.8 mm at both time points.

CONCLUSION

This study highlights antibiotics' antibacterial action against and Lactobacillus. The data imply that antibiotic efficacy varied by organism and drug concentration. These organisms' antibiotic resistance mechanisms and new antibiotic resistance methods need more study.

摘要

引言

疾病的发生和持续发展会受到口腔中致病微生物的定植或生理微生物群失衡的显著影响。因此,在本研究中,对各种常用抗生素的抗菌和抗真菌活性进行了测试。

材料与方法

本研究作为一项[此处信息缺失]研究开展。对常用抗生素阿莫西林克拉维酸钾(CV)、头孢曲松 - 头孢菌素(CF)和利奈唑胺针对微生物、乳酸杆菌以及[此处信息缺失]进行了测试。通过琼脂孔扩散法测试24小时和48小时后的“抑菌圈半径(毫米) - RZI”。

结果

对于[此处信息缺失],所测试的抗生素为CV(5微升和2.5微升)、CF(5微升和2.5微升)和利奈唑胺(5微升和2.5微升)。结果表明,每种抗生素浓度下的抑菌圈半径是一致的,在两个时间点的范围均为0.8 - 1.4毫米。对于乳酸杆菌,所测试的抗生素为CV(5微升和2.5微升)、CF(5微升和2.5微升)和利奈唑胺(5微升和2.5微升)。结果表明,抑菌圈半径在不同抗生素和浓度之间有所变化,在两个时间点的范围均为0.5 - 1.8毫米。

结论

本研究突出了抗生素对[此处信息缺失]和乳酸杆菌的抗菌作用。数据表明抗生素疗效因生物体和药物浓度而异。这些生物体的抗生素耐药机制和新的抗生素耐药方法需要更多研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01bf/11001070/b624a317e6a4/JPBS-16-223-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01bf/11001070/116e228d6e27/JPBS-16-223-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01bf/11001070/b624a317e6a4/JPBS-16-223-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01bf/11001070/116e228d6e27/JPBS-16-223-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01bf/11001070/b624a317e6a4/JPBS-16-223-g002.jpg

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