Department of Dental Surgery, Karpagam Faculty of Medical Sciences and Research, Coimbatore, Tamil Nadu, India, Phone: +91 9486646966, e-mail:
Department of Endodontics, Sri Ramakrishna Dental College and Hospital, Coimbatore, Tamil Nadu, India.
J Contemp Dent Pract. 2020 Dec 1;21(12):1325-1330.
To assess the application of clotrimazole (1%) as a complementary antifungal agent along with sodium hypochlorite (5.25%), chlorhexidine gluconate (2%), and doxycycline hydrochloride (5%) against .
Seventy freshly extracted single-rooted premolars with matured apices were collected, stored, and handled according to the Occupational Safety and Health Administration (OSHA) and the Center for Disease Control and Prevention (CDC) guidelines and recommendations. These were divided into three groups (two tests and one control group) depending on irrigants used. The efficacy of each irrigant group was compared. The observations were statistically analyzed by the multiple intergroup comparisons using ANOVA and Scheffe multiple comparisons ( < 0.001).
The sodium hypochlorite (group IA-mean 129.6) has shown a statistically significant decrease in colony-forming units (CFUs) ( < 0.01) on comparison with chlorhexidine [(IB) mean 190.2]. A similar result was obtained in comparison with the sodium hypochlorite group (IA) and doxycycline HCl group [(IC) mean 318.4] and also between the sodium hypochlorite group (IA) and the control group [(III) mean 554.2]. The intragroup comparison of group II, group IIA (mean 63.3), and group IIB (mean 73.8) showed no statistically significant difference. Group III (mean 554.2) was the least effective of all the subgroups.
Sodium hypochlorite showed better antifungal efficacy than chlorhexidine and doxycycline when used alone. The addition of clotrimazole increased the efficiency of doxycycline also, but it was less compared to sodium hypochlorite and chlorhexidine. Within the limitations of this study, the inclusion of 1% clotrimazole increased the antifungal efficacy of all the three irrigants.
Our study compared the efficacy of the various endodontic irrigants and also determined their efficiency with the addition of the antifungal agent. Clotrimazole (1%) addition in irrigating solutions showed better results and promoted faster healing.
评估克霉唑（1%）作为一种辅助抗真菌剂与次氯酸钠（5.25%）、葡萄糖酸氯己定（2%）和盐酸多西环素（5%）联合应用对抗 。
从 70 颗新鲜拔出的成熟根尖单根前磨牙中收集、储存和处理，符合职业安全与健康管理局（OSHA）和疾病控制与预防中心（CDC）的指南和建议。根据使用的冲洗液将这些分为三组（两组测试组和一组对照组）。比较每组冲洗液的疗效。通过方差分析和 Scheffe 多重比较对观察结果进行统计学分析（ < 0.001）。
与葡萄糖酸氯己定（IB 组，平均 190.2）相比，次氯酸钠（IA 组，平均 129.6）在降低菌落形成单位（CFUs）方面具有统计学意义（ < 0.01）。与次氯酸钠组（IA）和盐酸多西环素组（IC 组，平均 318.4）以及次氯酸钠组（IA）和对照组（III 组，平均 554.2）相比，也得到了类似的结果。组 II、组 IIA（平均 63.3）和组 IIB（平均 73.8）的组内比较无统计学意义。组 III（平均 554.2）是所有亚组中效果最差的。
单独使用时，次氯酸钠的抗真菌效果优于葡萄糖酸氯己定和盐酸多西环素。加入克霉唑也提高了盐酸多西环素的效率，但与次氯酸钠和葡萄糖酸氯己定相比效果较差。在本研究的限制范围内，加入 1%克霉唑提高了所有三种冲洗液的抗真菌效果。
本研究比较了各种根管冲洗液的疗效，并确定了加入抗真菌剂后的效果。在冲洗液中加入克霉唑（1%）可获得更好的效果并促进更快的愈合。
