Li Rui Min, Long Zhe, Ding Xiao Yan, Duan Li
Department of Operative Dentistry and Endodontics, Stomatology Hospital of General Hospital, Ningxia Medical University, China.
Ningxia Medical University, China.
Heliyon. 2024 Mar 29;10(7):e28826. doi: 10.1016/j.heliyon.2024.e28826. eCollection 2024 Apr 15.
Oral microecological dysregulation has been shown to be associated with various immune system disorders. Henoch-schonlein purpura (HSP) is an autoimmune small vessel inflammatory disease in children of uncertain etiology, and studies have suggested that streptococcal infection may be an influential factor in its development. However, the relationship between oral microecological dysregulation and HSP has not been clearly studied so far. In this study, an epidemiological survey on the oral health status of children with HSP was investigated in this paper, and collected dental plaque from four groups of children for 16SrDNA high-throughput sequencing to analyze the composition and changes of oral microbial diversity among different groups. The results showed that the oral health status of children with HSP was poor, except for the incidence of caries in the 5-year-old group, the caries rate and dmfs/DMFS in the 3,4 and 5-year-old groups were higher than the same age in the fourth Chinese Oral Health Epidemiological Survey. Moreover, the development of HSP is accompanied by disturbances in the oral microbiota; a decrease in the number of Firmicutes which producing butyric acid may be closely associated with the development of HSP; changes in the abundance of and may be a risk factor for the development of HSP.
口腔微生态失调已被证明与多种免疫系统疾病有关。过敏性紫癜（HSP）是一种病因不明的儿童自身免疫性小血管炎性疾病，研究表明链球菌感染可能是其发病的一个影响因素。然而，迄今为止，口腔微生态失调与HSP之间的关系尚未得到明确研究。在本研究中，本文对HSP患儿的口腔健康状况进行了流行病学调查，并采集了四组儿童的牙菌斑进行16SrDNA高通量测序，以分析不同组间口腔微生物多样性的组成和变化。结果显示，HSP患儿的口腔健康状况较差，除5岁组的龋病发病率外，3、4和5岁组的龋病率和dmfs/DMFS均高于第四次全国口腔健康流行病学调查中的同年龄段儿童。此外，HSP的发病伴随着口腔微生物群的紊乱；产丁酸的厚壁菌门数量减少可能与HSP的发病密切相关；[此处原文缺失两个菌属名称]丰度的变化可能是HSP发病的一个危险因素。
