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RECO注册研究中取栓支架尺寸对临床结局的影响。

Impact of stent retriever size on clinical outcomes in the RECO registry.

作者信息

Ding Yunlong, Mao Xiaoxiao, Bao Lei, Zhai Tingting, Wang Wenjuan, Gu Zhiqun, Liu Yan, Niu Jiali

机构信息

Department of Neurology, Jingjiang People's Hospital, The Seventh Affiliated Hospital of Yangzhou University, China.

Department of Imaging, Jingjiang People's Hospital, The Seventh Affiliated Hospital of Yangzhou University, China.

出版信息

Heliyon. 2024 Mar 30;10(7):e28873. doi: 10.1016/j.heliyon.2024.e28873. eCollection 2024 Apr 15.

Abstract

OBJECTIVE

In the RECO study, we investigated the impact of the operator's choice of stent retriever size on patients with internal carotid artery (ICA) occlusion.

METHODS

Data from the RECO Registry, a prospective multicentre study, were utilized. Patients who underwent mechanical thrombectomy (MT) were divided according to the size of the stent into the RECO 4 × 20 group, the RECO 5 × 30 group and the RECO 6 × 30 group. The outcome measures assessed in the study were the 3-month modified Rankin Scale (mRS) score, occurrence of any intracranial haemorrhage (aICH), workflow timing, recanalization success rate, number of attempts, and all-cause mortality within a 3-month period.

RESULTS

Analysis was conducted on a total of 89 patients with ICA occlusion. RECO 4 × 20, 5 × 30, and 6 × 30 stent retrievers were used in 19 (21.3%), 52 (58.4%), and 18 (20.2%) patients, respectively. The demographic and baseline characteristics showed considerable similarity across the three groups. The puncture-to-recanalization time of the RECO 6 × 30 group [56.5 min (IQR, 41.5-80.8)] was significantly shorter than that of the RECO 4 × 20 group [110 min (IQR, 47-135)]. In 10 out of 18 patients (55.6%), the RECO 6 × 30 stent retriever achieved reperfusion (modified Thrombolysis in Cerebral Infarction [mTICI] score 2b-3) after the initial attempt, surpassing the rates of 31.6% in the RECO 4 × 20 group and 32.7% in the RECO 5 × 30 group. In the RECO 4 × 20 group, the median number of passes was 2 (IQR, 1-3); in the RECO 5 × 30 group, it was 2 (IQR, 1-3); and in the RECO 6 × 30 groups, it was 1 (IQR, 1-2.5). There were no statistically significant differences observed among the three groups concerning aICH or good outcomes (mRS score 0-2).

CONCLUSION

Our study demonstrated the practical implications of stent-retriever size selection in the context of the MT for ICA occlusion. The routine use of a RECO 6 × 30 stent retriever holds the potential for early revascularization in clinical practice. The significant reduction in the puncture-to-reperfusion time and the greater first-pass effect associated with this stent size underscore its efficiency in treating ICA occlusion.

摘要

目的

在RECO研究中,我们调查了操作者选择的取栓支架尺寸对颈内动脉(ICA)闭塞患者的影响。

方法

利用来自前瞻性多中心研究RECO注册中心的数据。接受机械取栓(MT)的患者根据支架尺寸分为RECO 4×20组、RECO 5×30组和RECO 6×30组。该研究评估的结果指标为3个月改良Rankin量表(mRS)评分、任何颅内出血(aICH)的发生情况、工作流程时间、再通成功率、尝试次数以及3个月内的全因死亡率。

结果

对总共89例ICA闭塞患者进行了分析。分别有19例(21.3%)、52例(58.4%)和18例(20.2%)患者使用了RECO 4×20、5×30和6×30取栓支架。三组的人口统计学和基线特征显示出相当大的相似性。RECO 6×30组的穿刺至再通时间[56.5分钟(四分位间距,41.5 - 80.8)]明显短于RECO 4×20组[110分钟(四分位间距,47 - 135)]。18例患者中有10例(55.6%)在首次尝试后使用RECO 6×30取栓支架实现了再灌注(改良脑梗死溶栓[mTICI]评分2b - 3),超过了RECO 4×20组的31.6%和RECO 5×30组的32.7%。在RECO 4×20组中,平均通过次数为2次(四分位间距,1 - 3);在RECO 5×30组中为2次(四分位间距,1 - 3);在RECO 6×30组中为1次(四分位间距,1 - 2.5)。在aICH或良好结局(mRS评分0 - 2)方面,三组之间未观察到统计学上的显著差异。

结论

我们的研究证明了在ICA闭塞的MT背景下选择取栓支架尺寸的实际意义。常规使用RECO 6×30取栓支架在临床实践中具有早期血管再通的潜力。与该支架尺寸相关的穿刺至再灌注时间的显著缩短和更高的首次通过效果突出了其在治疗ICA闭塞方面的效率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0561/11002272/627cf826d5dc/gr1.jpg

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