Matsumoto Hisatake, Ogura Hiroshi, Oda Jun
Department of Traumatology and Acute Critical Medicine Osaka University Graduate School of Medicine Suita Osaka Japan.
Acute Med Surg. 2024 Apr 8;11(1):e944. doi: 10.1002/ams2.944. eCollection 2024 Jan-Dec.
Each patient with a critical illness such as sepsis and severe trauma has a different genetic background, comorbidities, age, and sex. Moreover, pathophysiology changes dynamically over time even in the same patient. Therefore, individualized treatment is necessary to account for heterogeneity in patient backgrounds. Recently, the analysis of comprehensive biomolecular information using clinical specimens has revealed novel molecular pathological classifications called subtypes. In addition, comprehensive biomolecular information using clinical specimens has enabled reverse translational research, which is a data-driven approach to the identification of drug target molecules. The development of these methods is expected to visualize the heterogeneity of patient backgrounds and lead to personalized therapy.
每一位患有败血症和严重创伤等危重病的患者都有不同的基因背景、合并症、年龄和性别。此外，即使是同一患者，其病理生理学也会随时间动态变化。因此，有必要进行个体化治疗以考虑患者背景的异质性。最近，利用临床标本对综合生物分子信息进行分析，揭示了称为亚型的新型分子病理分类。此外，利用临床标本的综合生物分子信息使反向转化研究成为可能，这是一种数据驱动的识别药物靶分子的方法。预计这些方法的发展将使患者背景的异质性可视化，并带来个性化治疗。
