Pène Frédéric, Ait-Oufella Hafid, Taccone Fabio Silvio, Monneret Guillaume, Sharshar Tarek, Tamion Fabienne, Mira Jean-Paul
Service de Réanimation Médicale, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, 27 Rue du Faubourg Saint-Jacques, 75014 Paris, France ; Faculté de Médecine, Université Paris Descartes, 12 Rue de l'Ecole de Médecine, 75006 Paris, France.
Service de Réanimation Médicale, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, 184 Rue du Faubourg Saint-Antoine, 75012 Paris, France ; Faculté de Médecine, Université Pierre-et-Marie-Curie, 27 Rue Chaligny, 75571 Paris, France.
Ann Intensive Care. 2015 Apr 30;5:8. doi: 10.1186/s13613-015-0050-3. eCollection 2015.
Experimental research has always been the cornerstone of pathophysiological and therapeutic advances in critical care medicine, where clinical observations and basic research mutually fed each other in a so-called translational approach. The objective of this review is to address the different aspects of translational research in the field of critical care medicine. We herein highlighted some demonstrative examples including the animal-to-human approach to study host-pathogen interactions, the human-to-animal approach for sepsis-induced immunosuppression, the still restrictive human approach to study critical illness-related neuromyopathy, and the technological developments to assess the microcirculatory changes in critically ill patients. These examples not only emphasize how translational research resulted in major improvements in the comprehension of the pathophysiology of severe clinical conditions and offered promising perspectives in critical care medicine but also point out the obstacles to translate such achievements into clinical practice.
实验研究一直是危重症医学病理生理学和治疗进展的基石，在危重症医学中，临床观察和基础研究以一种所谓的转化方法相互促进。本综述的目的是探讨危重症医学领域转化研究的不同方面。我们在此强调了一些典型例子，包括从动物到人的方法来研究宿主 - 病原体相互作用、从人到动物的方法来研究脓毒症诱导的免疫抑制、仍具局限性的人体研究方法来研究危重症相关神经肌肉病，以及评估危重症患者微循环变化的技术发展。这些例子不仅强调了转化研究如何在理解严重临床病症的病理生理学方面带来重大进展，并在危重症医学中提供了有前景的观点，还指出了将这些成果转化为临床实践的障碍。
