Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Beijing, China.
J Med Virol. 2024 Apr;96(4):e29602. doi: 10.1002/jmv.29602.
China experienced severe epidemics of multiple respiratory pathogens in 2023 after lifting "Zero-COVID" policy. The present study aims to investigate the changing circulation and infection patterns of respiratory pathogens in 2023. The 160 436 laboratory results of influenza virus and respiratory syncytial virus (RSV) from February 2020 to December 2023, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from June 2020 to December 2023, Mycoplasma pneumoniae, adenovirus, and human rhinovirus from January 2023 to December 2023 were analyzed. We observed the alternating epidemics of SARS-CoV-2 and influenza A virus (IAV), as well as the out-of-season epidemic of RSV during the spring and summer of 2023. Cocirculation of multiple respiratory pathogens was observed during the autumn and winter of 2023. The susceptible age range of RSV in this winter epidemic (10.5, interquartile range [IQR]: 5-30) was significantly higher than previously (4, IQR: 3-34). The coinfection rate of IAV and RSV in this winter epidemic (0.695%) was significantly higher than that of the last cocirculation period (0.027%) (p < 0.001). Similar trend was also found in the coinfection of IAV and SARS-CoV-2. The present study observed the cocirculation of multiple respiratory pathogens, changing age range of susceptible population, and increasing coinfection rates during the autumn and winter of 2023, in Beijing, China.
2023 年中国取消“零新冠”政策后，经历了多种呼吸道病原体的严重流行。本研究旨在探讨 2023 年呼吸道病原体的循环和感染模式变化。分析了 2020 年 2 月至 2023 年 12 月期间流感病毒和呼吸道合胞病毒（RSV）、2020 年 6 月至 2023 年 12 月期间严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）、2023 年 1 月至 12 月期间肺炎支原体、腺病毒和人鼻病毒的 160436 例实验室结果。我们观察到 SARS-CoV-2 和甲型流感病毒（IAV）的交替流行，以及 2023 年春夏季节 RSV 的非季节性流行。2023 年秋冬季节观察到多种呼吸道病原体的共同流行。本次冬季流行 RSV 的易感年龄范围（10.5，四分位距[IQR]：5-30）明显高于以往（4，IQR：3-34）。本次冬季流行中 IAV 和 RSV 的合并感染率（0.695%）明显高于上一次共同流行期间（0.027%）（p<0.001）。IAV 和 SARS-CoV-2 的合并感染也出现了类似的趋势。本研究观察到 2023 年秋冬季节多种呼吸道病原体的共同流行、易感人群年龄范围的变化以及合并感染率的增加。
