卵巢癌中前列腺素的形成。

Formation of prostaglandins by ovarian carcinomas.

作者信息

Bauknecht T, Siegel A, Meerpohl H G, Zahradnik H P

出版信息

Prostaglandins. 1985 May;29(5):665-72. doi: 10.1016/0090-6980(85)90128-5.

Abstract

Tissue contents of prostaglandins (PG) PGE2, PGE2a and 6-keto-PGF1a (degradation product of PGI2) were determined in specimens of advanced human ovarian cancer (n = 11). The PG levels (ng/mg tissue protein) varied widley: PGE2 17-515; PGF2a 2-43 and 6-keto-PGF1a 5-105. Tumors of patients without response to chemotherapy contained more PGE2, PGF2a and 6-keto-PGF1a than did tumors responding to chemotherapy. PG production was investigated in two ovarian carcinoma-derived cell lines. The ability of these cells to synthesize PG varied depending on the cell density. An increase of cell number was associated with a decrease of PG yield. PG formation was inhibited by indomethacin in a concentration-dependent manner. The present study suggests that ovarian carcinoma cells form PG in vivo and vitro.

摘要

在11例晚期人类卵巢癌标本中测定了前列腺素（PG）PGE2、PGE2α和6-酮-PGF1α（PGI2的降解产物）的组织含量。PG水平（ng/mg组织蛋白）差异很大：PGE2为17 - 515；PGF2α为2 - 43，6-酮-PGF1α为5 - 105。对化疗无反应患者的肿瘤中PGE2、PGF2α和6-酮-PGF1α的含量高于对化疗有反应的肿瘤。在两种卵巢癌衍生细胞系中研究了PG的产生。这些细胞合成PG的能力因细胞密度而异。细胞数量增加与PG产量降低相关。吲哚美辛以浓度依赖的方式抑制PG形成。本研究表明，卵巢癌细胞在体内和体外均可形成PG。