巴尔的摩口腔流行病学、疾病影响和 HIV 评估研究（BEEHIVE）研究方案：一项前瞻性队列研究。
Baltimore oral epidemiology, disease effects, and HIV evaluation study (BEEHIVE) study protocol: a prospective cohort study.
机构信息
University of Maryland School of Dentistry, 650 West Baltimore Street, Room 2209, Baltimore, MD, 21201, USA.
Johns Hopkins Medicine, 615 North Wolfe Street, Room E6533, Baltimore, MD, 21205, USA.
出版信息
BMC Oral Health. 2024 Apr 10;24(1):439. doi: 10.1186/s12903-024-04200-1.
BACKGROUND
As antiretroviral therapy has become widely available and highly effective, HIV has evolved to a manageable, chronic disease. Despite this health advancement, people living with HIV (PLWH) are at an increased risk for age-related non-communicable diseases (NCDs) compared to HIV-uninfected individuals. Similarly, PLWH are at an increased risk for selected oral diseases. PLWH with a history of injecting drugs experience an even greater burden of disease than their counterparts. The overall objective of the Baltimore Oral Epidemiology, Disease Effects, and HIV Evaluation (BEEHIVE) study is to determine the combined effects of HIV infection and NCDs on oral health status. The specific aims of the study are to: (1) determine to what extent HIV status influences access to and utilization of oral health care services; (2) determine to what extent HIV status affects self-reported and clinical oral health status; (3) determine to what extent HIV status influences the progression of periodontitis; and (4) determine to what extent HIV status impacts the periodontitis-associated oral microbiome signature.
METHODS
The BEEHIVE study uses a prospective cohort study design to collect data from participants at baseline and at a 24-month follow-up visit. Data are collected through questionnaire assessments, clinical examinations, and evaluation of oral microbiological samples to determine the drivers of oral disease among a high-risk population of PLWH with a history of injection drug use and prevalent comorbid NCDs. The established AIDS Linked to the Intravenous Experience (ALIVE) cohort serves as the source of participants for the BEEHIVE Study.
DISCUSSION
Upon completion of the BEEHIVE study, the knowledge gained will be important in informing future clinical and preventive interventions that can be implemented into medical and dental practice to ultimately help eliminate long-standing oral health inequities that PLWH experience.
背景
随着抗逆转录病毒疗法的广泛应用和高度有效，HIV 已演变为一种可控制的慢性疾病。尽管取得了这一健康进展，但与未感染 HIV 的个体相比，HIV 感染者（PLWH）患与年龄相关的非传染性疾病（NCDs）的风险增加。同样，PLWH 患某些口腔疾病的风险也增加。有注射毒品史的 PLWH 比他们的同龄人患病负担更大。巴尔的摩口腔流行病学、疾病效应和 HIV 评估（BEEHIVE）研究的总体目标是确定 HIV 感染和 NCD 对口腔健康状况的综合影响。该研究的具体目标是：（1）确定 HIV 状况在多大程度上影响口腔保健服务的获得和利用；（2）确定 HIV 状况在多大程度上影响自我报告和临床口腔健康状况；（3）确定 HIV 状况在多大程度上影响牙周炎的进展；（4）确定 HIV 状况在多大程度上影响牙周炎相关的口腔微生物组特征。
方法
BEEHIVE 研究采用前瞻性队列研究设计，在基线和 24 个月随访时收集参与者的数据。通过问卷调查、临床检查和口腔微生物样本评估收集数据，以确定有注射毒品史和常见合并 NCD 的高危 PLWH 人群中口腔疾病的驱动因素。已建立的艾滋病与静脉内经验相关（ALIVE）队列作为 BEEHIVE 研究的参与者来源。
讨论
BEEHIVE 研究完成后，获得的知识对于为未来的临床和预防干预措施提供信息非常重要，这些干预措施可以纳入医疗和牙科实践，最终有助于消除 PLWH 长期存在的口腔健康不平等问题。
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