基于姜黄素的眼用纳米乳剂对阿托品诱导的小鼠干眼的评价。
Evaluation of curcumin-based ophthalmic nano-emulsion on atropine-induced dry eye in mice.
作者信息
Hadipour Jahromy Mahsa, Qomi Mahnaz, Fazelipour Simin, Sami Nafiseh, Faali Farzaneh, Karimi Mehrnaz, Adhami Moghadam Farhad
机构信息
Herbal Pharmacology Research Center, School of Medicine, Dept of Pharmacology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Active Pharmaceutical Ingredients Research Center (APIRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
出版信息
Heliyon. 2024 Apr 3;10(7):e29009. doi: 10.1016/j.heliyon.2024.e29009. eCollection 2024 Apr 15.
BACKGROUND
One of the most efficient treatments for dry eye syndrome (DES) is to use nanocarriers as a potential delivery system. We aim to evaluate curcumin in a nano emulsion formulation.
METHODS
A new formulation containing 5.5% curcuminoid was used. DLS, Zeta potential, TEM, and HPLC tests were performed to determine the size and morphology. First, 30 mice were selected as atropine-induced dry eye models. Next, 25 mice in 5 groups were treated with the nano emulsion at different doses, and corneal tissues were separated for evaluation.
RESULTS
The DLS test results were indicative of the particles' stability. Nano curcumin appeared to be thoroughly effective in all groups, with the highest dose showing the most similarity to the healthy control group.
CONCLUSIONS
Curcumin-based nano emulsion eye drop is a promising candidate for DES management. However, further investigation is required to evaluate the possible risks in humans.
背景
干眼症（DES）最有效的治疗方法之一是使用纳米载体作为潜在的给药系统。我们旨在评估纳米乳剂配方中的姜黄素。
方法
使用一种含有5.5%姜黄素类化合物的新配方。进行动态光散射（DLS）、zeta电位、透射电子显微镜（TEM）和高效液相色谱（HPLC）测试以确定尺寸和形态。首先，选择30只小鼠作为阿托品诱导的干眼模型。接下来，将5组中的25只小鼠用不同剂量的纳米乳剂进行治疗，并分离角膜组织进行评估。
结果
DLS测试结果表明颗粒具有稳定性。纳米姜黄素在所有组中似乎都非常有效，最高剂量组与健康对照组最为相似。
结论
基于姜黄素的纳米乳剂滴眼液是治疗干眼症的一个有前景的候选药物。然而，需要进一步研究以评估其在人体中的潜在风险。
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