Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
J Mol Biol. 2024 Sep 1;436(17):168571. doi: 10.1016/j.jmb.2024.168571. Epub 2024 Apr 10.
Extracellular vesicles and particles (EVPs) play a crucial role in mediating cell-to-cell communication by transporting various molecular cargos, with small non-coding RNAs (ncRNAs) holding particular significance. A thorough investigation into the abundance and sorting mechanisms of ncRNA within EVPs is imperative for advancing their clinical applications. We have developed EVPsort, which not only provides an extensive overview of ncRNA profiling in 3,162 samples across various biofluids, cell lines, and disease contexts but also seamlessly integrates 19 external databases and tools. This integration encompasses information on associations between ncRNAs and RNA-binding proteins (RBPs), motifs, targets, pathways, diseases, and drugs. With its rich resources and powerful analysis tools, EVPsort extends its profiling capabilities to investigate ncRNA sorting, identify relevant RBPs and motifs, and assess functional implications. EVPsort stands as a pioneering database dedicated to comprehensively addressing both the abundance and sorting of ncRNA within EVPs. It is freely accessible at https://bioinfo.vanderbilt.edu/evpsort/.
细胞外囊泡和颗粒 (EVPs) 通过运输各种分子货物在细胞间通讯中发挥着关键作用，其中小非编码 RNA (ncRNAs) 具有特别重要的意义。深入研究 ncRNA 在 EVPs 中的丰度和分类机制对于推进其临床应用至关重要。我们开发了 EVPsort，它不仅提供了 3162 个样本中 ncRNA 谱分析的广泛概述，涵盖了各种生物流体、细胞系和疾病背景，还无缝集成了 19 个外部数据库和工具。这种集成包括 ncRNA 与 RNA 结合蛋白 (RBPs)、基序、靶标、途径、疾病和药物之间的关联信息。凭借其丰富的资源和强大的分析工具，EVPsort 扩展了其分析功能，以研究 ncRNA 的分类，识别相关的 RBPs 和基序，并评估其功能意义。EVPsort 是一个开创性的数据库，致力于全面解决 EVPs 中 ncRNA 的丰度和分类问题。它可以在 https://bioinfo.vanderbilt.edu/evpsort/ 免费获取。
